نتایج جستجو برای: lipid pathway
تعداد نتایج: 464691 فیلتر نتایج به سال:
The therapeutic potential of Wnt proteins has long been recognized but challenges associated with in vivo stability and delivery have hindered their development as drug candidates. By exploiting the hydrophobic nature of the protein we provide evidence that exogenous Wnt3a can be delivered in vivo if it is associated with a lipid vesicle. Recombinant Wnt3a associates with the external surface o...
The endoplasmic reticulum (ER) is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as "ER stress," has been linked to numerous pathological conditions, such as inflammation, cardiovascular diseases, and metabolic disorders. The liver plays a central role in regulating nutrient and lipid metabolism. Accumulating evidence implicate...
Previous studies from thislaboratory (1,2) have shown that pancreas contains two factors active in the lipid metabolism of the depancreatized dog maintained with insulin: (1) a heat-labile blood factor, the ingestion of which causes a rise above normal in all blood lipid constituents, in particular cholesterol; this factor is partially or completely destroyed when pancreas is subjected to autoc...
Interleukin-6 (IL-6) plays essential roles not only in the immune response, but also in hematopoiesis, and in the central nervous system. Dysregulated production of IL-6 has been found in chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA). Many reports have indicated that lipid levels, such as total cholesterol and triglyceride levels, are changed under inflammatory cond...
Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall polymers. GPIs follow a specific biosynthetic pathway in the endoplasmic reticulum. After the transfer of the protein onto the GPI-anchor, a lipid remodeling occur...
BACKGROUND Barely 10-20% of patients with metastatic colorectal cancer (mCRC) receive a clinical benefit from the use of anti-EGFR monoclonal antibodies (mAbs). We hypothesized that this could depends on their efficiency to reduce Store Operated Calcium Entry (SOCE) that are known to enhance cancer cells. RESULTS In the present study, we demonstrate that SOCE promotes migration of colon cance...
It is widely believed that HDL protects against atherosclerosis by removing excess cholesterol from arterial cells. Lipid-poor HDL apolipoproteins promote efflux of cholesterol, phospholipids, and other lipophilic molecules from cells by an active process mediated by a cell-membrane transporter called the ATP binding cassette transporter A-1 (ABCA1). ABCA1 either directly or indirectly transloc...
High density lipoprotein (HDL) phospholipids and apolipoproteins remove cellular lipids by two distinct mechanisms, but their relative contribution to reverse cholesterol transport is unknown. Whereas phospholipid-mediated cholesterol efflux from cultured cells reflects the activity of the HDL receptor SR-BI, apolipoprotein-mediated lipid removal is regulated in response to changes in cellular ...
Thanks to containing tumor-related molecules, small extracellular vesicles (sEVs) are emerging as biomarkers in tumor liquid biopsy and commonly employed diagnose a specific cancer. However, pan-cancer screening method for pre-symptomatic patients is crucial achieving the early cancer detection. Herein, lipid-protein capture system on herringbone (HB) microfluidic chip (HBEV-Chips) isolate mult...
The lipogenic phenotype is a metabolic hallmark of cancer cells. Sterol regulatory element–binding proteins (SREBP) are key transcriptional factors to regulate biosynthesis of cholesterol and fatty acids. It has been poorly understood how the lipogenic phenotype in cancer cells is regulated and how it augments their malignant properties. Here we describe roles of the melanoma antigen gangliosid...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید