Coal-fired power units, now balancing shortages in the system, must be characterised by increasingly higher flexibility of operation. This means faster start-ups and capacity for frequent decreases increases output. These processes cause large temperature gradients elements unit turbine lead to an increase stress level. At such operating regime it is impossible ensure safety based on start-up c...

A major challenge to broadening oncology applications for inhibitors of the ubiquitin-proteasome system (UPS) is the identification of UPS-dependent cancer pathways predictive of tumors responsive to peptidomimetic inhibitors of its 20S core protease activity. To inform clinical studies evaluating UPS inhibitors as breast cancer therapeutics, seven phenotypically diverse human breast cancer cel...

Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients ...

DNA re-identification is used for a broad suite of applications, ranging from cell line authentication to forensics. However, current re-identification schemes suffer from high latency and limited access. Here, we describe a rapid, inexpensive, and portable strategy to robustly re-identify human DNA called 'MinION sketching'. MinION sketching requires as few as 3 min of sequencing and 60-300 ra...

This paper presents a fast top-down visual attention method to downsize the search space of template matching. Such a method first generates patterns representing the local structures, and then calculates the pattern distributions representing the template and its surroundings. From here two separate operations are performed: the "pattern weight" is first introduced, which describes how well a ...

The so-called "ubiquitin-proteasome system" (UPS) is a multicomponent molecular apparatus that catalyzes the covalent attachment of several copies of the small protein ubiquitin to other proteins that are generally (but not always) destined to proteasomal degradation. This enzymatic cascade is crucial for the maintenance of intracellular protein homeostasis (both in physiological conditions and...

Background and Objectives: Given the limited number of studies on Ramadan fasting and military performance, we conducted this study to identify the effect of Ramadan fasting on physical fitness performances in army cadets. Methods: Twenty healthy males were randomly selected from a larger sample group. The subjects were divided into fasting (n=10) and non-fasting (n=10) groups. They performed v...

It is now clear that the two broad sets of reactions in the ubiquitin-proteasome system (UPS), the conjugative and degradative steps, are intricately coupled in vivo and that there are numerous factors that aid in the handling and delivery of ubiquitylated proteins to the proteasome. The report from Richly et al (2005)[this issue of Cell]) suggests how several of the known players in this proce...

This article aims to investigate the effects of relationship banking and market rivalry on small firm liquidity. Our major objective is determine how bank concentration affect three crucial acts business liquidity (cash funds, line-ups credit, employment credit), both separately collectively. Due their significance for ’s profitability, value, sustainability, we concentrate cash assets (Harford...

We construct simply connected, minimal, symplectic 4-manifolds with exotic smooth structures and each one Seiberg–Witten basic class up to sign, on the Noether line between half lines by star surgeries introduced Karakurt Starkston, using complex singularities. also certain configurations of singularities in rational elliptic surfaces geometrically, without any monodromy arguments. By these con...