Dipeptidyl-peptidase-IV (DPP-4) inhibitors are oral antidiabetic agents that can be administered as monotherapy in patients with contraindications to metformin or metformin intolerance, and in combination with other oral compounds and/or insulin. DPP-4 inhibitors act in a glucose-dependent manner and only increase insulin secretion and inhibit glucagon secretion under hyperglycemic conditions. ...

Patients with diabetes are at risk of early renal function decline. Therefore, kidney function needs monitoring at least once per year. Once the glomerular filtration rate (GFR) is less than 60 ml/min, the pharmacokinetics of antidiabetic drugs may be altered. Sulfonylurea and glinide therapies are associated with a risk of hypoglycaemia which is increased in the presence of renal impairment. M...

The knowledge regarding the risk of bullous pemphigoid (BP) in patients with type 2 diabetes (T2D) taking dipeptidyl peptidase 4 inhibitors (DPP4i) is based on case reports, pharmacovigilance database analyses, randomized clinical trials and retrospective observational studies. To further investigate relationship between DPP4i BP to characterize demographic, immunological profile associated we ...

Background: In addition to lifestyle modifications, metformin is the recommended first-line pharmacotherapy for patients with type 2 diabetes mellitus (T2DM). The use of glimepiride or linagliptin as add-on (GM LM) has been noticed on prescriptions in major pharmacies Nigeria.
 Aims: aim this study was compare efficacy T2DM.
 Methods: A preliminary case-crossover randomized experiment...

INTRODUCTION Current estimates indicate that diabetes affects approximately 26 million people in the U.S. (8.3% of the population). Almost 19 million people have diabetes, and the disease remains undiagnosed in an estimated 7 million people. Diabetes is associated with significant morbidity, including kidney failure, nontraumatic lower-limb amputations, neuropathies, hypertension, periodontal d...

The novel reverse phase-high performance liquid chromatography (RP-HPLC), stability indicating method was developed for determination of linagliptin (LGP) and its related substances in linagliptin and metformin HCl (MET HCl) tablets by implementing design of experiment to understand the critical method parameters and their relation with critical method attributes; to ensure robustness of the me...