WaterLOGSY and STD experiments are widely used as NMR-based screening techniques in drug research. In the present study, an improved STD pulse sequence was developed, and its efficiency and applicability of observing the ligand signals were evaluated compared with the WaterLOGSY experiment. A combination of presaturation, a WET sequence and subsequent repeated Z-filters can provide the most eff...

The promoters of cell adhesion are ligands, which are often attached to flexible tethers that bind to surface receptors on adjacent cells. Using a combination of Monte Carlo simulations, diffusion reaction theory, and direct experiments (surface force measurements) of the biotin-streptavidin system, we have quantified polymer chain dynamics and the kinetics and spatial range of tethered ligand-...

A novel Ru(II) sensitiser A597 containing the 4,4'-dioctylamido-2,2'-bipyridine ancillary ligand is synthesised without the need for purification steps. It shows an irreversible oxidation at 0.92 V in the cyclic voltammogram and an absorbtion at 539 nm in the UV-vis spectrum corresponding to an (1)MLCT transition. Preliminary DFT calculations reveal that the HOMO is localised on the ruthenium m...

We report in this paper the epitaxial growth of PbS shells over PbSe nanocrystal quantum dots (NQDs) with monolayer-precision. The core-shell infrared NQDs were ligand-exchanged with short-chain octadmine, and the photoluminescence efficiency of the surface-engineered core-shell nanoparticles was substantially higher than that of the plain core structures undergoing the same surface processing,...

In order to enhance the charge balance of organic near infrared (NIR) electroluminescent devices, an ancillary ligand pic-SCz which was covalently linking bipolar group SCz (composed PS (S) and tBuCz (Cz)) pic (SCz=3,6-di-tert-butyl-9-(4-(phenylsulfonyl)phenyl)-9H-carbazole; = phenyl sulfone; 3,6-di-tert-butylcarbazole; pic= 2-picolinic acid) developed for iridium (III) complex (TPA-BTz-Iq)2Ir(...

Molecular copper water oxidation electrocatalysts have been extensively studied in recent years for their potential use artificial photosynthetic systems solar energy conversion. Although ligand modification and its ability to influence catalytic properties is a key advantage of molecular systems, there are, as yet, few examples systematic studies these effects. Our oxidatively resistant pyalk ...

In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3'-untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the message to the cytosol, stabilization of the mRNA and/or altering its translational efficiency. Suppression of HuR using siRNA resulted in an attenuation of the 3T3-L1 differentia...