OBJECTIVES To measure colloid osmotic pressure in interstitial fluid (COP(i)) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantation time on COP(i). MATERIAL AND METHODS In 50 healthy volunteers interstitial fluid (IF) was collected by subcutaneous implantation of multi-filamento...

This study was aimed to evaluate the possible alert signals of paraesthesia by local anaesthetics, focusing on those used in dentistry. A case/non-case study of spontaneous adverse events recorded in FAERS (FDA Adverse Event Reporting System) between 2004 and 2011 was performed. Cases were represented by the reports of reactions grouped under the term 'Paraesthesias and dysaesthesias' involving...

BACKGROUND The objective of this study was to assess the utilization of local anesthetics by emergency physicians (EP) and pediatric physicians (PP) who performed a lumbar puncture (LP) in pediatric patients from birth to 24 months of age. METHODS We conducted a prospective study of children that received an LP at a university tertiary referring hospital. A convenience sample included childre...

This study compared pain on application, pain on venipuncture, cost, and convenience of 4 analgesic agents used for venipuncture. A convenience sample of 280 preoperative subjects was assigned randomly to 1 of 4 groups. Group 1 received 2.5% lidocaine--2.5% prilocaine cream (LPC) topically, Group 2 received dichlorotetrafluoroethane spray (DCTF), Group 3 received 0.5% lidocaine subcutaneously, ...

The analgesic effect and the usefulness of EMLA cream 5% in connection with venous blood-sampling was investigated in 42 Tanzanian schoolchildren. Approximately 2.5 g EMLA was applied to the right cubital fossa for a minimum of 120 min. The analgesic effect was pronounced--93% of the venepunctures were pain-free and no child experienced severe pain. No adverse reactions were observed and the ch...

We present a 54-year-old woman who suffered eczematous eruptions on her face after the administration of lidocaine and mepivacaine for dental surgeries. Patch tests showed delayed-type-hypersensitivity to the amide local anesthetics lidocaine and mepivacaine with cross reaction to other amynoacylderivatives (prilocaine,bupivacaine) but not articaine.

BACKGROUND Recent developments in anesthesia applicable to family practice settings are reviewed. METHODS MEDLINE was searched using the key words "EMLA"; "iontophoresis"; "lidocaine," "tetracaine, adrenaline, cocaine"; and "lidocaine, epinephrine, tetracaine." RESULTS AND CONCLUSIONS Clinical experience has shown that there is a definite and evolving role for the newer methods of office an...

a number of studies has shown that orally administered sweet-tasting solutions reduce signs of pain during painful procedures. the local anesthetic cream emla has recently been shown to be safe for use in neonates. the present study aimed to compare the pain-reducing effect of emla cream with that of orally administered glucose during venipuncturing in newborns in yazd city. a randomized, contr...