Lactoferrin (LF) is a multifunctional protein in the transferrin family that has been widely used food and pharmaceutical products. However, it susceptible to denaturation during thermal processing, which can diminish functionality bioavailability of LF final product. Coacervation with biopolymers demonstrated as promising approach protect from denaturation. This work aims study formation condi...

BACKGROUND Lymphatic filariasis (LF) occurs when filarial parasites are transmitted to humans through mosquitoes. The filarial worms affect the lymphatic system which leads to abnormal enlargement of body parts, chronic pain, disability, and social discrimination. In 1999, a commitment was made to eliminate LF from the Pacific Region by 2010. The Pacific Program to Eliminate LF began, with Vanu...

Lactoferrin (Lf) is an iron-binding multi-functional glycoprotein which has numerous physiological functions such as iron transportation, anti-microbial activity and immune response. In this study, different in silico approaches were exploited to investigate Lf protein properties in a number of mammalian species. Results showed that the iron-binding site, DNA and RNA-binding sites, signal pepti...

To quantitatively evaluate the effect of insulin on cardiac sympathetic nerve activity (SNA) and analyze clinical factors associated with insulin sensitivity for the regulation of SNA in diabetics, 29 Japanese type 2 diabetics without neuropathy were recruited. A 2-h control study and a 2-h hyperinsulinemic euglycemic glucose clamp study were performed. From the power spectral analysis of R-R i...

Executive summary The project aimed to support lymphatic filariasis (LF) control efforts in Zambia and Tanzania, through operational research and capacity building. It was carried out in close collaboration with the national LF control programmes, and with locally registered PhD and Master students. Much new insight has been gained on the geographical distribution and epidemiology of LF in Zamb...

BACKGROUND AND AIMS Methotrexate (MTX) safety is questioned by the risk of inducing liver fibrosis (LF). As transient elastography (FibroScan®) is an effective non-invasive technique to evaluate LF, our aims were to assess LF in MTX-treated patients, to evaluate LF regarding treatment duration and cumulative dose, and to determine differences depending on the underlying disease. PATIENTS AND ...

We instrument a higher-order logic programming search procedure to generate and check small proof witnesses for the Twelf system, an implementation of the logical framework LF. In particular, we extend and generalize ideas from Necula and Rahul [16] in two main ways: 1) We consider the full fragment of LF including dependent types and higher-order terms and 2) We study the use of caching of sub...

BACKGROUND Hypotension due to vasodilatation after spinal anesthesia (SA) may be harmful. Heart rate variability, an indirect measure of autonomic control, may predict hypotension. METHODS One hundred patients were studied. Retrospectively, heart rate variability was analyzed in 30 patients, classified depending on the lowest systolic blood pressure (SBP) after SA. Seventy patients were studi...

BACKGROUND AND PURPOSE Based on their ability to chelate metals, hydroxamate molecules and siderophores have been successfully used as metalloenzyme inhibitors. As the anthrax toxin lethal factor (LF) is a zinc (Zn)-metallopeptidase, an investigation of the ability of some small non-siderophore hydroxamate compounds, 5 hydroxamate-containing siderophores, and 1 catecholate siderophore was under...

DNA vaccines provide an attractive technology platform against bioterrorism agents due to their safety record in humans and ease of construction, testing, and manufacture. We have designed monovalent and bivalent anthrax plasmid DNA (pDNA) vaccines encoding genetically detoxified protective antigen (PA) and lethal factor (LF) proteins and tested their immunogenicity and ability to protect rabbi...