BACKGROUND Mechanisms regulating breast cancer lymph node metastasis are unclear. Staining of CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1) in human breast tumors was used, along with in vitro techniques, to assess involvement in the metastatic process. METHODS 148 sections of primary invasive breast cancers, with 10 yr follow-up, were stained with anti-CLEVER-1....

Transmissible gastroenteritis virus (TGEV) infection of piglets results in a very rapid and massive release of IFN-alpha in serum and secretions. The objective of this work was to characterize the IFN-alpha-producing cells (IPC) in tissues of TGEV-infected piglets. Caesarean-derived colostrum-deprived piglets were infected orally with the TGEV virulent Miller strain and IPC were characterized i...

Introduction: Previous studies have been conflicting with regards to the effects of peripheral leukocyte apoptosis on clinical outcomes in hemorrhagic and septic shock. No studies have examined the correlation between peripheral blood PMN apoptosis and outcomes in trauma patients following resuscitation from hemorrhagic shock in vivo. Methods: Pre-operative, post-operative, and 24-hour venous s...

background: exercise and consumption of green tea affect the aging process. however, the effect of exercise training combined with green tea extract on leukocyte telomere length, quality of life (qol) and body composition in aging has so far been unclear and inconsistent. objective: the aim of the present study was to determine the effectiveness of aerobic training intervention and green tea ex...

background: an enchondroma is a benign and a well-differentiated chondrosarcoma is an invasive chondroid tumor with high recurrence potential. in spite of biologic differences, these two tumors have very similar histopathologic appearance. it has been shown that the biologic nature of the connective tissue around benign and malignant tumors varies in the number of mast cells. the aim of this st...

common variable immunodeficiency (cvid) is a heterogeneous heritable disease characterized by arrest in b cell differentiation. an association between cvid and two hla haplotypes, haplotype i (hla-a1, hla-b8, hla-dr3) and haplotype ii (hla-a29, hla-b44, hladr7)has been previously documented. in the present study, we have attempted to find an association between susceptibility to cvid and hla cl...

microscopy as “field based test” was compared with is900 blood pcr for the diagnosis and estimationof prevalence of mycobacterium avium subspecies paratuberculosis (map) in domestic livestock withclinical johne’s disease (jd). of 252 animals screened, 39.3 and 13.1% were positive by faecal microscopyand blood pcr, respectively. proportional agreement between “microscopy” and blood pcr was subst...

allergic airway inflammation is characterized by elaboration of cytokines and chemokines leading to recruitment of inflammatory leukocytes, predominantly eosinophils, to the airways. granulocyte macrophage colony stimulating factor (gm-csf) is generated in the lungs of human subjects with asthma in response to allergen challenge and is necessary for the development of allergen-induced bronchial...

background:intraventricular hemorrhage is the most common intracranial hemorrhage in premature infants. the objective of this study was to investigate the relationship between intraventricular hemorrhage and blood leukocyte count. materials and methods:this was a cross-sectional simple sampling study conducted from the beginning of 2006 to 2010 in ali-asghar children’s hospital. inclusion crite...