The care for younger patients with acute myeloid leukaemia (AML) requires fully equipped medical facilities that have routine experience the management of this aggressive disorder. Two indepen...

Seventeen bone marrow recipients transplanted for acute leukaemia (8), chronic leukaemia (1), severe aplastic anaemia (3), and various inborn errors of metabolism (5) had 22 episodes of documented infection in the late (greater than 3 months) post-transplant period. Serum C-reactive protein concentrations were considerably increased in patients with bacterial infections, but not in those with v...

The incidence of acute leukaemia in children with Down's syndrome is substantially greater than it is in normal children (Stewart, Webb, and Hewitt, 1958; Holland, Doll, and Carter, 1962), and the leukaemia complicating Down's syndrome is more often of myeloblastic type than is the case in childhood leukaemia generally (Boggs, Wintrobe, and Cartwright, 1962; Warkany, Schubert, and Thompson, 196...

Studies of risk factors for acute leukaemia are inconclusive. This case-control study was done in West Azerbaijan province, Islamic Republic of Iran, to determine the relationship between birth weight and acute leukaemia in children aged under 15 years. For every patient 2 age- and sex-matched controls were selected from hospital and community populations. Of 130 cases diagnosed over the period...

The relation of brain cancer and mortality from leukaemia to electrical occupations was investigated in a case-control study based on all deaths in 1985 and 1986 in the 16 states in the United States that report occupational data from death certificates to the national vital statistics registry. The case series comprised all 2173 men who died of primary brain cancer (International Classificatio...

Introduction The standard approach to the diagnosis of acute leukaemia and myelodysplasia has been based on the morphology and percentage of malignant haemopoietic cells in peripheral blood and in an aspirated sample of bone marrow. The FAB group reports on acute leukaemia have emphasised the value of additional information gained from cytochemistry,' and immunological studies and cytogenetics ...

A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types are applied to cases of acute leukaemia. Proposals based on conventional morp...

Major differences exist in the nature of leukaemia and lymphoma in low-income African children compared to those in the high-income countries. These include the absence of the peak incidence of acute lymphoblastic leukaemia (ALL) in under-five-year olds that characterizes the disease in high-income countries. Conversely, chloroma association with acute myelogenous leukaemia (CA-AML/AMML) and Bu...

The present study, which included 280 cases of acute leukaemia and 288 controls, investigated the relationship between childhood acute leukaemia (AL) and non-occupational exposure to pesticide during pregnancy and childhood. Acute leukaemia was associated to home insecticide use during pregnancy and during childhood (OR=1.8 [1.2-2.8], OR=1.7 [1.1-2.4], respectively) and garden insecticide use d...

The cell of origin and triggering events for leukaemia are mostly unknown. Here we show that the bone marrow contains a progenitor that expresses renin throughout development and possesses a B-lymphocyte pedigree. This cell requires RBP-J to differentiate. Deletion of RBP-J in these renin-expressing progenitors enriches the precursor B-cell gene programme and constrains lymphocyte differentiati...