The roots of Hymenocardia acida are used in traditional African medicine to treat mainly erectile dysfunction. This study aims evaluate the lethal and sub-lethal toxicities aqueous extract two rodents species, namely Mus musculus Rattus norvegicus. acute intraperitoneal oral were determined by method Miller Tainter. Subchronic toxicity with doses 500 1000 mg/kg body weight was assessed accordin...

A new pleuromutilin derivative with excellent antibacterial activity, 14-O-[(2-amino-1,3,4-thiadiazol-5-yl) thioacetyl] mutilin (ATTM), may serve as a possible lead compound for the development of antibacterial drugs. However, in vivo efficacy and toxicity evaluations of this compound have not been performed. In this study, we evaluated the efficacy of ATTM by measuring the survival of mice aft...

The acute and chronic toxicity of zinc to wild mottled sculpin (Cottus bairdi) was measured with 13-d and 30-d flow-through toxicity tests, respectively. Exposure water hardness was 48.6 mg/L as CaCO3 and 46.3 mg/L as CaCO3 in the acute and chronic tests, respectively; pH was slightly above neutral; and temperature near 12 degrees C. The median lethal concentration (LC50) after 96 h was 156 mic...

The authors reviewed cases investigated by the Palm Beach Medical Examiner’s Office in which postmortem toxicologic studies indicated the presence of methadone over the period from 1998 to 2002, to examine the role of the drug in these deaths. There were 139 methadonepositive cases, including 75 in which the death was attributed to combined drug toxicity and 23 to methadone toxicity alone. Meth...

The acute toxicity of physically and chemically dispersed crude oil and the dispersant Corexit 9500 were evaluated for key Arctic species. The copepod Calanus glacialis, juvenile Arctic cod (Boreogadus saida), and larval sculpin (Myoxocephalus sp.) were tested under conditions representative of the Beaufort and Chukchi Seas during the ice-free season. The toxicity of 3 water-accommodated fracti...

The available data on the combined action of rare earth elements and heavy metals are contradictory. Therefore, goal presented work is relevant – to determine effects solutions copper, lanthanum salts their equimolar mixtures under controlled conditions for Daphnia magna Straus. It has been established that death D. over 50% in containing Cu2+ observed at a calculated concentration 0.05 mg/L (0...

The aims of this study was to evaluate the acute and sub-acute toxicity Solanum aethiopicum Linn Gilo aqueous leaves extract in Wistar rats. Female rats received a single dose (2000, 3000, 4000 5000 mg/kg/ bw) for toxicity. Both, male female 300,500 800 bw during 21 days measurements. Blood sample collected determination some haematological, biochemical oxidative stress parameters. Besides, his...

The study's objectives were to investigate the acute toxicity and related biochemical effects of levamisole ivermectin in mice. 24 h oral median lethal dose (LD50) was determined by up-and-down method 155.5 mg/ kg body weight. treated mice showed signs poisoning represented excessive grooming, lacrimation, piloerection, straub tail, tachycardia, bulged eyes, tremor, convulsion finally death wit...