نتایج جستجو برای: leptin receptor rene polymorphism

تعداد نتایج: 699261  

Journal: : 2022

Identification of Polymorphism Melanocortin 4 Receptor Gene and its Association with Egg Production Traits in Turkey

2014
Paddy KC Janssen Daan Touw Dave H. Schweitzer Marcel D. Waldinger

PURPOSE Nonresponse to any selective serotonin reuptake inhibitor (SSRI) treatment is rare. In this study, we aimed to investigate ejaculation delay nonresponse to paroxetine treatment in men with lifelong premature ejaculation (PE) who were also known to be nonresponders to other SSRIs. MATERIALS AND METHODS Five males with lifelong PE who were known nonresponders to paroxetine and other ser...

Journal: : 2023

The purpose of the work – to analyze data from world literature regarding thedetermination probable role progesterone receptor gene polymorphism asa factor in occurrence premature birth.Conclusions. 1. Progesterone plays a significant inthe mechanisms development and course miscarriage, negative pregnancy outcomeand low birth weight newborns. 2. probability threat birthin different periods gest...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Cecilia Garofalo Diego Sisci Eva Surmacz

PURPOSE Obesity is a risk factor for breast cancer development in postmenopausal women and correlates with shorter disease-free and overall survival in breast cancer patients, regardless of menopausal status. Adipose tissue is a major source of leptin, a cytokine regulating energy balance and controlling different processes in peripheral tissues, including breast cancer cell growth. Here, we in...

Journal: :Reproduction 2004
M C Henson K F Swan D E Edwards G W Hoyle J Purcell V D Castracane

Leptin produced by both adipose tissue and the placental trophoblast, has been proposed to regulate numerous aspects of human conceptus development. Although recent animal studies have suggested an additional role for the polypeptide in fetal lung maturation, no evidence has been reported in primates. Therefore, we employed the baboon (Papio sp.), a well-characterized primate model for human pr...

Journal: :Nutricion hospitalaria 2011
P Gómez Abellán C Gómez Santos J A Madrid F I Milagro J Campion J A Martínez J A Luján J Ma Ordovás M Garaulet

INTRODUCTION Circadian variability of circulating leptin levels has been well established over the last decade. However, the circadian behavior of leptin in human adipose tissue remains unknown. This also applies to the soluble leptin receptor. OBJECTIVE We investigated the ex vivo circadian behavior of leptin and its receptor expression in human adipose tissue (AT). SUBJECTS AND METHODS Vi...

Journal: :The Journal of endocrinology 2008
Gideon Hen Sera Yosefi Ana Ronin Paz Einat Charles I Rosenblum Robert J Denver Miriam Friedman-Einat

We report on the construction of a leptin bioassay based on the activation of chicken leptin receptor in cultured cells. A human embryonic kidney (HEK)-293 cell line, stably transfected with the full-length cDNA of chicken leptin receptor together with a STAT3-responsive reporter gene specifically responded to recombinant human and Xenopus leptins. The observed higher sensitivity of chicken lep...

2018
Takami Murakami Munechika Enjoji Susumu Koyama

Obesity causes hyperleptinemia. We have previously shown that D2 receptor-mediated inhibition of ventral tegmental area (VTA) dopaminergic neurons is attenuated in diet-induced mice with obesity. Consequently, we hypothesized that high concentrations of serum leptin during obesity might modulate D2 receptor-mediated effects on VTA dopaminergic neurons. To investigate our hypothesis, we examined...

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