Abstract The leptin-melanocortin pathway is playing a pivotal role for central body weight regulation. melanocortin 4 receptor (MC4R) essential to induce satiety after activation by the endogenous ligands α-/β-melanocyte-stimulating hormone. relevance of biased signaling exemplified an MC4R agonist, which has been approved treatment rare forms monogenic obesity. Here discussed as new option dev...

The hypothalamic-pituitary-thyroid axis is down-regulated during starvation, and falling levels of leptin are a critical signal for this adaptation, acting to suppress preprothyrotropin-releasing hormone (prepro-TRH) mRNA expression in the paraventricular nucleus of the hypothalamus. This study addresses the mechanism for this regulation, using primary cultures of fetal rat hypothalamic neurons...

Various studies have demonstrated that increased leptin levels and obesity are inversely related to cognitive decline in menopausal women. It is hypothesized that adiposity is inversely correlated with cognitive decline, as women with increased weight are less vulnerable to diminishing cognition. However, it is increasingly observed that menopausal women, even with increased adiposity, experien...

Abstract Introduction Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of upper airway during sleep, is present in 90% OHS patients. Leptin, an adipocyte-produced hormone, acts leptin receptor (LEPRb) positive neurons and was implicated pathophysiology OSA OHS. ...

Several studies have recently investigated the role of leptin, the adipocyte-secreted hormone, in the growth and reproduction of rodents, humans, and domestic animals. The present study was designed to explore the expression of leptin and its receptor in pig spermatozoa. Successful Western blot evidenced a 16 kDa band for leptin and six isoforms, ranging from 120 to 40 kDa, for the leptin recep...

Physiological conditions of low leptin levels like those observed during negative energy balance are usually characterized by the suppression of luteinizing hormone (LH) secretion and fertility. Leptin administration restores LH levels and reproductive function. Leptin action on LH secretion is thought to be mediated by the brain. However, the neuronal population that mediates this effect is st...

Trombley, S. 2014. Regulation of Leptin by Sexual Maturation and Energy Status in Male Atlantic Salmon (Salmo salar L.) Parr. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1151. 54 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8956-4. Leptin is a peripheral adiposity signal and a key hormone in energy balance regulation in mam...

Leptin is an adipose tissue derived hormone, which has a crucial role in regulating food intake and energy expenditure. Leptin is also an important metabolic regulator, which maintains glucose and lipid homeostasis. After identification of its influences on body weight and fat mass in leptin deficient obese rodent models, leptin supplementation was used for the treatment of obesity in human. Ho...