BACKGROUND Gastrointestinal stromal tumors (GISTs) harbor gain-of-function mutations of the c-kit tyrosine kinase receptor. Imatinib mesylate is an inhibitor of c-kit and is indicated in the treatment of chronic myeloid leukemia and GISTs. Reported adverse effects of imatinib include hypopigmentation, depigmentation, and hyperpigmentation. Although the exact mechanism by which these occur is un...

Solar lentigines (SLs) are a major social and cosmetic concern to many individuals. To date, simple 2D monolayer cell cultures exposed UV or classical reconstructed pigmented epidermis without dermal compartment used explore the cellular molecular mechanisms involved in SL disorders. However, none of these conventional approaches recapitulates complexity SLs. Here, we developed first 3D full-th...