Variant DNA sequences flanking the human insulin gene were found in the Danish population using restriction endonucleases (restriction fragment length polymorphism). The frequencies of these DNA sequences were determined in 47 non-insulin-dependent diabetics and 93 control individuals. We report an association between a restriction fragment length polymorphism of the insulin gene and NIDDM.

Garlic belongs to the Allium genus, which includes more than 750 species divided into 60 taxonomic groups. It is cultivated in many countries throughout world for bulb and used as a spice functional food. The plant vegetatively propagates. This review will focus on origins, biology, analysis of genetic diversity, pharmacological properties garlic. appears from this synthesis that sativum derive...

Purpose This study aimed to explore the effects of genetic polymorphisms in metabolic enzymes on relative telomere length changes and explore the mechanism of canceration induced by omethoate. Materials and Methods 180 long-term omethoate-exposed workers and 115 healthy controls were recruited. Real-time PCR method was applied to determine the relative telomere length in peripheral blood leuk...

  Purpose: Estrogen as a crucial hormone during pregnancy acts by two types of receptors.   Estrogen receptor alpha, expressed by estrogen receptor 1 (ESR1) gene, is more abundant and   exists in all human reproductive systems. Association of ESR1 gene polymorphism has been   shown in some reproductive fields such as spontaneous abortion, endometriosis-related infertility   and in vitro fertili...

Background: This is a case-control study to determine the relationship between endothelial nitric oxide synthase (eNOS) gene -786T/C polymorphism in women with unexplaiend recurrent abortion in comparison with healty women.Materials and Methods: 95 women with history of at least 2 unexplaiend recurrent abortion in the reproductive age range 20-35 years as patients group and 95 healty women (age...

BACKGROUND/AIM To investigate polymorphism characteristics of HIV-1 gpl20 and its 5 hypervariable regions. MATERIALS AND METHODS Length polymorphism, potential number of N-linked glycosylation sites (PNGSs), and sequence characteristics of nearly all available global gp120 and its 5 hypervariable regions from HIV-1 subtypes A, B, C, D, G, and H were analyzed. RESULTS We found that the major...

Background Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility. We determined the possible association between CYP1A1 MspI and GSTM1 null polymorphism in the pathogenesis of endometriosis. MaterialsAndMethods Ninety seven cases of endometr...