NF-kappaB is a key transcription factor that regulates inflammatory processes. In the present study, we tested the hypothesis that blockade of NF-kappaB ameliorates cardiac remodeling and failure after myocardial infarction (MI). Knockout mice with targeted disruption of the p50 subunit of NF-kappaB (KO) were used to block the activation of NF-kappaB. MI was induced by ligation of the left coro...

The question of whether reductions in blood flow occur under resting conditions in viable nonischemic myocardium in patients with coronary artery disease has been debated for 3 decades. Some early measurements reported reductions in resting left ventricular flow that seemed difficult to attribute to admixture of scar tissue with normally perfused myocardium.1,2 Others failed to show differences...

CONDENSED ABSTRACT We analyzed actomyosin cross-bridge kinetics in human atrial and ventricular muscle strip preparations by using sinusoidal length changes from 0.1 to 60 Hz. The minimum stiffness frequency was higher in atrial than in ventricular human myocardium and lower in failing than in non-failing left ventricular human myocardium. beta-Adrenergic stimulation increased the minimum stiff...

catheterization. Echocardiography would tend to overlook obstruction on the right side since the right ventricular outflow tract is not readily apparent and seldom evaluated under inotropic stimulation. This finding helps to further the concept that this disease involves the myocardium as a whole and it manifests itself as an obstruction where the anatomic features allow the changing size and s...

During the early developmental period, ventricular myoarchitecture undergoes a transition from a smooth-walled cardiac tube, to left and right ventricular chambers filled with a sponge-like network of trabecular struts. We measured the quantitative changes of ventricular myocardium properties in normal stage 21-29 chick embryos and after chronic verapamil suffusion, which is known to decrease w...

BACKGROUND The mechanisms of ventricular enlargement and dysfunction during postinfarct remodeling remain largely unknown. Although global left ventricular architectural changes after myocardial infarction are well documented, differences in function between adjacent and remote noninfarcted myocardium during left ventricular remodeling have not been investigated. These functional differences ma...

Ranks. San Francisco, McGraw-Hill, 1975, p 125 15. Lehman EL: Nonparametrics: Statistical Methods Based on Ranks. San Francisco, McGraw-Hill, 1975, p 316 16. Gibson DG, Prewitt TA, Brown DJ: Analysis of left ventricular wall movement during isovolumic relaxation and its relation to coronary artery disease. Br Heart J 38: 1010, 1976 17. Streeter DD Jr, Hanna WT: Engineering mechanics for success...

To determine the effects of age on the myocardium, the functional and structural characteristics of the heart were studied in rats at 4, 12, 20, and 29 months of age. Mean arterial pressure, left ventricular pressure and its first derivative (dP/dt), and heart rate were comparable in rat groups up to 20 months. During the interval from 20 to 29 months, elevated left ventricular end-diastolic pr...

Left ventricular function on patients with heart disease is now evaluated by echocardiography, but these dimensional changes are erroneous in the patient supported by left ventricular assist device because of mechanical unloading for the failing heart. Left ventricular end-systolic pressure-volume relationship provides theoretically most reliable left ventricular contractility. Recently, some p...

Speckle-tracking analysis is a new available tool in order to assess left ventricular function in cardiology. Its novelty relies on the technological ability to track natural acoustic markers (known as speckle) within the myocardium during the cardiac cycle. This technology allows the evaluation of myocardium strain during systole and diastole. To date, global longitudinal strain (GLS) has been...