The quantification of mechanical interventricular asynchrony (IVA) was investigated. In 12 dogs left bundle branch block (LBBB) was induced by radio frequency ablation. Left ventricular (LV) and right ventricular (RV) pressures were recorded before and after induction of LBBB and during LBBB + LV apex pacing at different atrioventricular (AV) delays. Four IVA measures were validated using compu...

Background The diagnosis of coronary artery disease (CAD) in patients with LBBB represents a clinical challenge. The presence of fragmented QRS (fQRS) complex on surface ECG may be related to myocardial ischemia, scarring or fibrosis. Objectives To investigate the relation between fQRS and the presence and severity of CAD in patients with LBBB. Patients and methods 56 patients with symptoms...

Introduction: ischemic left bundle branch block (LBBB) is coronary occlusion. We report an atypical case of de novo LBBB in relation to a tight right lesion. Material and methods: Mr H, 53 years old with no modifiable risk factors, consulted for typical angina pain evolving since 4 hours. The per-critical ECG showed complete criteria acute ischemia. Coronary angiography lesion the artery that w...

OBJECTIVES We compared mechanical dyssynchrony and the impact of cardiac resynchronization therapy (CRT) in failing hearts with a pure right (RBBB) versus left bundle branch block (LBBB). BACKGROUND Cardiac resynchronization therapy is effective for treating failing hearts with conduction delay and discoordinate contraction. Most data pertain to LBBB delays. With RBBB, the lateral wall contra...

To elucidate the abnormalities in ventricular activation sequence in human left bundle branch block (LBBB), epicardial mapping was performed in five patients, ages 52-58 years, undergoing coronary bypass surgery, and the results were compared with similar data published from patients without conduction defect. Three patients had chronic and two patients intraoperative LBBB. ECGs during LBBB rev...

OBJECTIVES To examine the use of thrombolytic treatment in patients with suspected acute myocardial infarction (AMI) and left bundle branch block (LBBB). To evaluate electrocardiographic criteria for the identification of AMI in the presence of LBBB, and examine the implications of using these criteria in the clinical setting. METHODS A retrospective study over two years, based in two Sheffie...

BACKGROUND Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure. METHODS AND RESULTS Resynchronization Reverses Remo...

BACKGROUND Recently, the deleterious effects of left bundle branch block (LBBB) on left ventricular systolic function have been taken into consideration. OBJECTIVES The present study aimed to identify underlying factors that predict left ventricular ejection fraction (LVEF) deterioration in patients suffered from complete LBBB. PATIENTS AND METHODS In a retrospective case-control study, the...

BACKGROUND The impact of QRS morphology and duration on the effectiveness of cardiac resynchronization therapy (CRT) has been usually assessed separately. The interaction between these 2 simple ECG parameters and their effect on CRT has not been systematically assessed in a large-scale clinical trial. METHODS AND RESULTS The Resynchronization-Defibrillation for Ambulatory Heart Failure Trial ...

We report myocardial perfusion SPECT pattern in four subsequent patients with rate dependent left bundle branch block (LBBB). Three females and one male (aged 48, 51, 63 and 67 years) were studied. None of the patients had history of typical chest pain and all suffered from atypical chest pain or dyspnea on exertion. All patients were tested for baseline and serial heart rate, blood pressure, a...