OBJECTIVE To develop a novel mouse model of acquired subglottic stenosis (SGS) using heterotopic transplanted laryngotracheal complexes (LTCs). DESIGN Pilot randomized controlled animal study. SUBJECTS Forty-eight C57BL/6 mice. INTERVENTIONS Twenty-four donor C57BL/6 mice underwent LTC harvesting. The LTCs were then implanted deep to a cutaneous dorsal flap in 24 allogenic recipients. Six...

OBJECTIVE To explore the effect of mitomycin treatment on the pediatric airway following laryngotracheal reconstruction. DESIGN Randomized, double-blind, placebo-controlled trial. PATIENTS Children aged 2 to 17 years with subglottic or upper tracheal stenosis undergoing laryngotracheal reconstruction at a single, tertiary care, children's hospital. INTERVENTION At the time of extubation o...

List of illustrations List of Tables Abbreviations Acknowledgements Chapter 1 1.I Background and Aims of Thesis Chapter 2 2.I Embryology 2.II Anatomy 2.III History of Airway Surgery 2.III.a Tracheostomy and Airway intubation 2.III.b Laryngoscopy 2.III.c Bronchoscopy 2.III.d Surgery for laryngotracheal Stenosis 2.III.e Tracheobronchial stenting 2.III.f Lasers 2.III.g Mitomycin-C Chapter 3 3.I Su...

Background Laryngotracheal resection and anastomosis (LTRA) is a reliable treatment for benign subglottic laryngotracheal stenosis (BSLTS), but data on functional outcomes are scarce. We assessed the surgical of LTRA in BSLTS. Methods retrospectively reviewed consecutive patients who underwent BSLTS 2007 to 2018. The 30-day were mortality, complications, success rate. At last follow-up, complet...