BACKGROUND Preclinical animal models to study laryngeal cancer are nonexistent. The purpose of this study was to describe a novel mice laryngeal cancer model. METHODS A total of 18 six-week-old A/J mice were used. Animals underwent microdirect laryngoscopy, superficial larynx scratching, and instillation of N-methyl-N-nitrosourea (MNU) at 2 different concentrations (15 μL and 30 μL) or dimeth...

Introduction: A rare case of basaloid squamous cell carcinoma (BSCC) of the larynx, which has not been previously reported, is described. Case Report: A 60-year-old man was presented to the Otolaryngology Department with progressive dyspnoea and dysphagia to solids for over a period of 1 week. Direct laryngoscopy revealed a tumour at the laryngeal aspect of the epiglottis, which prolapsed into...

Laryngeal cancer is a frequent malignancy originating from the squamous vocal epithelium in a multi-stage fashion in response to environmental carcinogens. Although most cases can be cured by surgery and/or radiotherapy, advanced and relapsing disease is common, and biomarkers of such dismal cases are urgently needed. The cancer genome of laryngeal cancers was recently shown to feature a signat...

Abstract Background One of the most problematic issues laryngeal carcinoma is recurrence after surgery one causes this study tries to find its relevance peri neural invasion. Aim work To determine whether there a relationship between perineural invasion and cervical nodal metastases squamous cell carcinoma. Methods Between December 2019 September 2020, was conducted on 30 individuals who had SC...

We report a case of recurrent laryngeal nerve palsy caused by coalworkers' pneumoconiosis with progressive massive fibrosis (PMF). This illustrates that PMF alone may be added to the list of lesions which can cause recurrent laryngeal nerve palsy. However, efforts should always be made to exclude more common causes, in particular bronchogenic carcinoma, before attributing the palsy to PMF.

BACKGROUND Gastroesophageal reflux is suspected to be an etiological factor in laryngeal and pharyngeal cancer. The aim of this study was to establish, using a non-invasive method, whether laryngopharyngeal reflux (LPR) appears more often in patients with early laryngeal cancer than in a control group. PATIENTS AND METHODS We compared the pH, the level of bile acids, the total pepsin and the ...

Laryngeal carcinoma is a common tumor of the head and neck region. This study aimed to examine the outcomes of laryngectomy in elderly patients with laryngeal carcinoma. One-hundred twenty-two patients (male, 117; female, 5) aged 60 years or older (range, 60-94 years) who underwent laryngectomy between 1996 and 2010 were included. All patients were diagnosed with squamous cell carcinoma of the ...

BACKGROUND Gain of 3q26 is frequently observed in squamous cell carcinomas of mucosal origin, including those originating in the head and neck region. The human telomerase RNA component (hTERC) gene, which is located on chromosome 3q26, encodes for an RNA subunit of telomerase that maintains the length of telomeres through cellular divisions, and is activated in malignant diseases. The present ...

BACKGROUND The clinical relevance of the carbohydrate antigen Sialyl Lewis a (SLea) as a serum tumor marker in diagnosis and follow-up treatment is unquestioned in a broad spectra of human carcinomas. Overexpression of this antigen is combined with poor prognosis and malignant relapse. The aim of our study was the systematic investigation of SLea expression in squamous cell carcinoma of the lar...

To clarify the expression level and methylation of esophageal cancer related gene 4 in laryngeal malignant tumor adjacent tissues, to explore its potential correlation with clinicopathological characteristics patients is objective study. The clinical samples were collected from 20 primary Xiangtan Central Hospital December 2017 2018. detected by next-generation sequencing technology. In 15 case...