Hypophonia is an early symptom in Parkinson's disease (PD) that involves an increase in laryngeal muscle activity, interfering with voice production. Our aim was to use an animal model to better understand the role of different dopamine receptor subtypes in the control of laryngeal neurophysiology. First, we evaluated the combined effects of SCH23390-a D(1) receptor antagonist with a D(2) recep...

The locus activation region (LAR) of the human beta-globin-like gene cluster is characterized by a group of four DNase I hypersensitive sites, which arise specifically in erythroid tissues and are required for a normal pattern of beta-globin-like gene expression. The hypersensitive sites are found at positions 6.1, 10.9, 14.7, and 18 kilobase pairs (kbp) 5' of the epsilon-globin gene. Recently ...

Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents, but it is not known whether these alterations contribute to the pathogenesis of insulin resistance. To address this question, we generated transgenic mice that overexpress human LAR, specifically i...

BACKGROUND To estimate the risk of radiation induced second cancers after radiotherapy using deep-inspiration breath-hold (DI) technique with three-dimensional conformal (3DCRT) and volumetric arc therapy (VMAT) for patients with Hodgkin's lymphoma (HL). METHODS Early-stage HL with mediastinal and supraclavicular involvement was studied using an Alderson phantom. A whole body CT was performed...

Linguistic knowledge plays an important role on phrase movement in statistical machine translation. To efficiently incorporate linguistic knowledge into phrase reordering, we propose a new approach: Linguistically Annotated Reordering (LAR). In LAR, we build hard hierarchical skeletons and inject soft linguistic knowledge from source parse trees to nodes of hard skeletons during translation. Th...

INTRODUCTION Hyperinsulinism associated with Beckwith-Wiedemann syndrome (BWS) can occur in about 50% of cases, causing hypoglycemia of variable severity. Parenteral use of octreotide may be indicated if unresponsive to diazoxide. There is limited data on use of octreotide in BWS. OBJECTIVE Chart review describing 2 cases with BWS and hypoglycemia treated with long acting Octreotide as a mont...

Yalnızca biçimbilgisel düzeyde ve süreçlerle değil; sözdizimsel, sözlüksel, edimbilgisel başkaca düzey de şekillenip ortaya çıkabilen birbirinden bağımsız çok farklı yollarla işaretlenebilen edilgenlik, Türkçede çokluğu ifade etmede kullanılan -lAr ile ikincil olarak işaretlenebilmektedir. Daha üçüncü kişi eylem çekiminde, tüm zamanlarda kiplerde biçimbiriminin edilgenliği işaretleme işlevi, ço...

OBJECTIVE Our laboratory has previously created 2 strains of rabbits with genetically determined high-atherosclerotic response (HAR) and low-atherosclerotic response (LAR). The aim of the present study was to identify new genes of atherosclerosis susceptibility in macrophages from the 2 strains. METHODS AND RESULTS Suppression subtractive hybridization was used to screen for genes with higher...

A novel liquid argon (LAr) purity monitor was developed with a sensitivity to elec-tronegative impurities of the order of ppb (O 2 equivalent). Such a high purity is e.g. needed in a LAr drift chamber. The principle is to measure the lifetime of quasifree electrons in LAr, since this is the important parameter for the operation of a drift chamber. Free electrons are produced by ionizing the LAr...

Patients with nonresectable metastatic neuroendocrine tumors (NETs) experience symptoms of hormone hypersecretion including diarrhea, flushing, and bronchoconstriction, which can interfere with quality of life [Anthony and Vinik (2011) Pancreas, 40:987]. Treatment with a long-acting release formulation of octreotide, a somatostatin analog, can help to alleviate these symptoms. Although high dos...