Due to its availability, low cost, flat geometry, and transparency, the ex ovo chick embryo has become a major vertebrate animal model for the study of morphogenetic events, such as gastrulation2, neurulation3-5, somitogenesis6, heart bending7,8, and brain formation9-13, during early embryogenesis. Key to understanding morphogenetic processes is to follow them dynamically by time-lapse imaging....

INTRODUCTION To facilitate translational work in medications development for smoking cessation, we have developed a human laboratory analogue of smoking lapse behavior. Our paradigm models 2 critical features of smoking lapse: the ability to resist the first cigarette and subsequent ad libitum smoking. In this paper we present the results of 2 studies designed to develop and validate the effect...

Time-lapse imaging is a technique that allows for the direct observation of the process of morphogenesis, or the generation of shape. Due to their optical clarity and amenability to genetic manipulation, the zebrafish embryo has become a popular model organism with which to perform time-lapse analysis of morphogenesis in living embryos. Confocal imaging of a live zebrafish embryo requires that ...

A system capable of reliably detecting lapses in responsiveness ('lapses') has the potential to increase safety in many occupations. We have developed an approach for detecting the state of lapsing with second-scale temporal resolution using data from 15 subjects performing a one-dimensional (1D) visuomotor tracking task for two 1 h sessions while their electroencephalogram (EEG), facial video,...

There are a number of ongoing developments in the 4D gravity method for time-lapse production and sequestration problems. Complex model construction is an essential component for meaningful feasibility studies and data interpretation in 4D. In the case of oil reservoirs, for example, the 4D gravity method must deal with very small density contrasts at depth, and overly simplistic model represen...

Projections of amplified climate change in the Arctic are attributed to positive feedbacks associated with the retreat of sea ice and changes in the lapse rate of the polar atmosphere. Here, a set of idealized aquaplanet experiments are performed to understand the coupling between high-latitude feedbacks, polar amplification, and the large-scale atmospheric circulation. Results are compared to ...

AIMS To evaluate the associations of treatment and an additive genetic efficacy score (AGES) based on dopamine functional polymorphisms with time to first smoking lapse and point prevalence abstinence at end of treatment among participants enrolled into two randomized clinical trials of smoking cessation therapies. DESIGN Double-blind pharmacogenetic efficacy trials randomizing participants t...

Despite significant financial loss and implicit cost associated with a long-term care insurance (LTCI) policy lapse, cancellation of a LTCI policy prior to becoming eligible for benefits is a common phenomenon in this market. Using data from the 1996-2012 Health and Retirement Study (HRS), I investigate why do individuals let their LTCI policy lapse and suffer a financial loss of premium paid w...