BACKGROUND Study of human lacrimal cell biology is limited by poor access to tissue samples, heterogeneous cell composition of tissue and a lack of established lacrimal epithelial markers. In order to further our understanding of lacrimal cell biology, we sought to find a better marker for human lacrimal epithelial cells, compared to what has been reported in the literature. METHODS We utiliz...

BACKGROUND The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis betwee...

Ocular adnexal lymphoma (OAL) is a rare tumor with an incidence of 0.2 per 1,00,000 individuals. However, it constitutes the most common orbital tumor especially in older population with an incidence ranging from 11% to 24%. OAL can involve conjunctiva, orbital soft tissues, eyelid, or adnexal structures such as lacrimal gland and lacrimal drainage system. The most common primary OAL is low-gra...

OBJECTIVE To compare the efficacy of external dacryocystorhinostomy (DCR) with and without intraoperative application of mitomycin-C in patients with chronic dacryocystitis. STUDY DESIGN An experimental study. PLACE AND DURATION OF STUDY Department of Ophthalmology, Bahawal Victoria Hospital (BVH), Bahawalpur, from September 2009 to December 2010. METHODOLOGY One hundred and sixty patient...

The precorneal tear film with its lacrimal, mucinous, and meibomian secretions is es­ sential for maintaining the structural in­ tegrity of the cornea in general and for en­ suring optical regularity of its anterior surface in particular. Replenishment and mixing of its components is brought about by normal blinking when the upper eyelid tarsal conjunctiva, preceded by the marginal tear strip, ...

OBJECTIVE To determine the usefulness of "routine" lacrimal sac biopsy to evaluate unsuspected neoplasm or systemic disease in patients with acquired nasolacrimal duct obstruction. DESIGN Noncomparative, interventional case series with histopathologic correlation. PARTICIPANTS Review of charts revealed histopathologic reports on 302 specimens from 258 patients who had undergone routine dacr...

PURPOSE The purpose of the present study was to investigate the roles of caspase 1 and extracellular signal-regulated kinase (ERK) in inflammation-induced inhibition of lacrimal gland secretion. METHODS Lacrimal gland inflammation was induced by injection of lipopolysaccharide (LPS; to study the role of caspase 1) or IL-1beta (to study the role of ERK). Lacrimal gland protein secretion was me...

PURPOSE This study was conducted to seek sex differences in mRNA expression in normal mouse lacrimal glands. Gene expression differences in the lacrimal gland may contribute to susceptibility to lacrimal gland or ocular surface disease. METHODS A differential display analysis was performed on poly(A)+ RNA isolated from male and female Swiss Webster mouse exorbital lacrimal glands. Four potent...

introduction: motor vehicular accidents are one of the leading causes of death in young men and severe complications in all age groups. this study was carried out to evaluate eye injuries secondary to motor vehicular accidents that have a high rate of occurrence in yazd province. methods: this descriptive, cross- sectional study was conducted through case series method. simple sampling, i.e. ce...

PURPOSE Differential display analysis was used to look for gender differences in lacrimal gland gene expression. The expression of a female-specific mouse lacrimal gland mRNA that encoded pancreatic lipase-related protein 1 (PLRP1) was identified and characterized. METHODS Differential display analysis of the exorbital lacrimal glands of male and female Swiss Webster mice detected a potential...