The rabbit is customarily used for the preparation of anti-human globulin serum, but there are several objections to the choice of this animal. These are: (1) The volume of serum obtained is small. To maintain supplies it is necessary either to have several animals producing the reagent, or to hyperimmunize and bleed the rabbits used too frequently, which in turn results in a less specific reag...

Control methods used to manage unwanted impacts of the European rabbit in Australia and New Zealand include the use of toxic bait containing the anticoagulant pindone. Towards increased certainty in evaluating the animal welfare impacts of pindone poisoning in rabbits, we recorded behavioral and post-mortem data from rabbits which ingested lethal quantities of pindone bait in a laboratory trial...

background: microsporidia species are obligatory intracellular agents that can in­fect all major animal groups including mammals, birds, fishes and insects. whereas world­wide human infection reports are increasing, the cognition of sources of infec­tion particularly zoonotic transmission could be helpful. we aimed to detect zoono­tic microsporidia spore in fecal samples from some animals with ...

Experimental ocular and neurosyphilis has been investigated in this laboratory during the past 3 years in three species-rabbits, owl monkeys, and squirrel monkeys. Rabbits were selected as a control to the primate experiments because of the large available literature concerning experimental syphilis in the rabbit. During the course of these studies, it became apparent that many rabbits purchase...

Recent electron microscopic studies of normal and pathological synovia have given a fresh insight into the structure and function of this tissue. The structure of human (Barland, Novikoff, and Hamerman, 1962; Roy, Ghadially, and Crane, 1966) and guinea-pig synovium (Wyllie, More, and Haust, 1964) has been studied in some detail, but only brief accounts of normal rabbit synovium can be found in ...

Cadmium and zinc concentrations in kidney and liver have been measured under different exposure situations in different species including man. The results show that zinc increases almost equimolarly with cadmium in kidney after long-term low-level exposure to cadmium, e.g., in man, horse, pig, and lamb. In contrast, the increase of zinc follows that of cadmium to only a limited extent, e.g., i...

In previous reports from this laboratory [ 1,2] we have shown that in guinea pig liver mitochondria there is a competition for energy between PEP and citrulline synthesis. Fatty acids are known to affect the intramitochondrial PEP* formation. Octanoate has been found to inhibit PEP production [3,4], while oleate results in a stimulation of this process [5,6] . In the present investigation the e...

Animal models are important tools to predict human in vivo percutaneous absorption/penetration. Monkey, pig, rat, rabbit, guinea pig, hairless rodents, such as hairless rat, hairless mouse, hairless guinea pig and hairless dog, are among the most used animals for this purpose. Each animal model has its own advantages and weakness or limitation. To better correlate animal data with human skin ab...

Rabbit hemorrhagic disease virus (RHDV), the causative agent of rabbit hemorrhagic disease, is an important member of the caliciviridae family. Currently, no suitable tissue culture system is available for proliferating RHDV, limiting the study of the pathogenesis of RHDV. In addition, the mechanisms underlying RHDV translation and replication are largely unknown compared with other calicivirid...

• In contrast to the extensive literature dealing with the chemical changes in the circulating blood in atherosclerosis and the composition of the atheromatous plaques, there is relatively little information concerning the metabolic alterations of the arterial tissue associated with the development of atherosclerosis. In previous investigations from this laboratory on the metabolism of arterial...