BACKGROUND Ultrasonic vocalizations (USVs) emitted by muroid rodents, including laboratory mice and rats, are used as phenotypic markers in behavioral assays and biomedical research. Interpretation of these USVs depends on understanding the significance of USV production by rodents in the wild. However, there has never been a study of muroid rodent ultrasound function in the wild and comparison...

The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, and adaptation to captivity, is of limited use for the study of fitness-driven b...

Many behavioural studies of laboratory house mice have sought functional explanations for their results. This raises the problem of the comparability of behaviour with that of wild house mice from whose naturally selected repertoire the behaviour of laboratory strains has been derived. This in turn requires careful choice of measures to ensure that subtle changes in response during the selectio...

Abstract Tissue regeneration is a process that recapitulates and restores organ structure function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice ( Mus ), the limited to center of wound unlike those observed African spiny Acomys ) mice. mechanics been implicated as an integral part tissue morphogenesis. Here, we use WIHN model investigate me...

Abstract Background The leaves of Phlogacanthus thyrsiflorus are used as an anthelmintic remedy by the tribes upper Assam. This study evaluates its toxic effects in laboratory bred mice and rats. Mice were orally dosed for 5 days, whereas rats 28 days variations behaviour, feeding habits blood parameters recorded. vital organs processed histopathology to observe any alternations from normal arc...

despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. recently, human cytomegalovirus (hcmv) was reported as a risk factor for breast cancer. the aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? in this experiment seventeen samples of razi/a mice with spontaneous breast cancer were being gathered fr...

Information regarding the prevalence of infectious agents in mice in pet shops in Japan is scarce. This information is particularly useful for minimizing the risk of potential transmission of infections to laboratory mice. Therefore, we surveyed infectious agents in mice from pet shops in Kanagawa and Tokyo, Japan. The survey was conducted in 28 mice from 5 pet shops to screen for 47 items (17 ...

Infection of laboratory mice by the Murid herpesvirus 4 (MHV-4) is a much studied model system for gammaherpesvirus pathogenesis. Little, however, is known about its natural host range, epidemiology and pathogenesis outside the laboratory. We have studied MHV-4 infection in free-living murids in the UK. Using a combination of serology and PCR analysis, we found that MHV-4 was endemic in wood mi...

The feed preference of two species wild mice, the house mouse (Mus musculus), and mound-building spicilegus) was investigated (kept in our laboratory for 25 generations). Our interest focused on (i.e. if mice choose type closest to their natural food). proximate composition granulated feeds offered differed minimally; crude fat fibre content mixture higher, only this contained insect protein. B...

Incidence of anxiety-like disorders in humans has been shown to decrease with aging; however, it is still under debate whether there are similarities mice, which would support the use mouse models understanding neuronal network changes that regulate behavior aging. One most common tests used assess laboratory animals elevated plus maze (EPM). Although several variables, such as room brightness ...