EGFR is deregulated, in several types of cancer, by three mechanisms: (1) activating gene mutations; (2) overexpression the transmembrane form and (3) altered ligand expression. Selective inhibitors have been suggested as first-line therapy lung cancer patients harboring mutations, tumors pancreas certain histotypes ovarian tumors. Carbohydrate antigen 125(CA125) Human Epididymis 4 are being us...

The H4IIE cell bioassay has proven utility as a screening tool for planar halogenated hydrocarbons (PHHs) and structurally similar chemicals accumulated in organisms from the wild. This bioassay has additional applications in hazard assessment of PHH exposed populations. In this review, the toxicological principles, current protocols, performance criteria, and field applications for the assay a...

onion thrips, thrips tabaci, is the most important pest of onion in isfahan. onion growers often rely on the pesticide spraying. imidacloprid is frequently used against this pest. to investigate the thrips resistance to this insecticide, 10 onion-growing regions of isfahan were selected. after their laboratory rearing, certain concentrations of imidacloprid were applied to these populations, us...

is an important human fungal pathogen, in terms of both its Candida albicans clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, a...

We examined the health of mature blue ash, Fraxinus quadrangulata, in two forests southwestern Ohio relation to that white F. americana, and potential importance oviposition preferences larval resistance persistence ash. Both ash were largely unaffected by emerald borer 2012. By 2018, nearly 90% trees observed these had full or canopies, as opposed less than 20% encountered our studies. In 2021...

The crude extracts of fruits of Sapindus mukorossi, leaves of Cestrum nocturnm, Cestrum diurnum, and Asclepias curassavica were tested under laboratory conditions against Aedes aegypti, a vector of dengue and chikungunya, for their larvicidal properties. Bioassay experiments carried out with crude alcoholic extracts of Sapindus mukorossi, Cestrum nocturnm, Cestrum diurnum, Asclepias curassavica...

An endophytic fungus was isolated from surface sterilized leaf segments of Anoectochilus setaceus, an orchid endemic to Sri Lanka, and was identified as Xylaria sp. by morphological characters and DNA sequencing. Bioassay-guided chromatographic fractionation of the organic extract of a laboratory culture of this fungus led to the isolation of the known antibacterial helvolic acid. Helvolic acid...