Brevinin-2R is a novel non-hemolytic defensin that was isolated from the skin of the frog Rana ridibunda. It exhibits preferential cytotoxicity towards malignant cells, including Jurkat (T-cell leukemia), BJAB (B-cell lymphoma), HT29/219, SW742 (colon carcinomas), L929 (fibrosarcoma), MCF-7 (breast adenocarcinoma), A549 (lung carcinoma), as compared to primary cells including peripheral blood m...

Brevinin-2R is a novel non-hemolytic defensin that was isolated from the skin of the frog Rana ridibunda. It exhibits preferential cytotoxicity towards malignant cells, including Jurkat (T-cell leukemia), BJAB (B-cell lymphoma), HT29/219, SW742 (colon carcinomas), L929 (fibrosarcoma), MCF-7 (breast adenocarcinoma), A549 (lung carcinoma), as compared to primary cells including peripheral blood m...

Formocresol is common treatment in exposed pulp of primary teeth at caries, trauma and damaged with cavity preparation. Although, clinical and radiographic success and good clinical results are observed, dentistry societies are still searching for materials interchangeable with formocresol. Suab1 is a phytochemical agent that was selected because of its anti- bleeding effect. In this study, we ...

Additive manufacturing is becoming increasingly important in dentistry for the production of surgical guides. The development of cost-effective desktop stereolithography (SLA) printing systems and the corresponding resins makes this novel technique accessible to dental offices and dental laboratories. The aim of the study was to reveal the response of soft tissue cells to Clear and Dental SG re...

Introduction: Traditionally Prangos ferulacea root is being used as an effective wound healing agent especially for pus-filled wounds both in human and stocks in the western north of Iran. Regarding the subject we decided to study P. ferulacea roots essential oil (PFE) for its antimicrobial and wound healing activities. Methods: The in vitro wound healing activity of PFE was evaluated in the mo...

Cells are established to sense and respond the properties, including nano- microscale morphology, of substrate they adhere to, which opens up possibility tailor bioactivity. With this background, potential tilted TiO2 nanostructures grown by oblique angle sputtering affect fibroblasts with particular focus on inducing anisotropy in cell behavior is explored. By depositing at different angles re...

Cancer is currently ongoing to be a significant health problem threatening human health. Hydrazone compounds constitute popular class of organic used in novel drug discovery studies therapy cancer. In the current study, preparation and structural characterization some heterocyclic hydrazone (7-12) their anticancer capacities against HeLa cervical cancer MCF-7 breast cell lines were reported. Th...

As a consequence of the proinflammatory environment occurring in dialytic patients, cytokine overproduction has been implicated in hemodialysis co-morbidity. However, there are discrepancies among the various studies that have analyzed TNF-alpha synthesis and the presence of peripheral blood mononuclear cell (PBMC) priming in this clinical setting. We measured bioactive cytokine by the L929 cel...

AIM The aim of the study was to investigate antitumor activity of thymoquinone (TQ) and thymohydroquinone (THQ) in vitro and in vivo. MATERIALS AND METHODS In the in vitro experiments, L929 mouse broblasts and two tumor cell lines (squamous cell carcinoma (SCC VII) and fibrosarcoma (FsaR)) were used. The cells were cultured with 0.1 or 0.01 mg/ml TQ or THQ for 24 h, and cytotoxicity assay was...

TITANIUM SURFACE FOR SOFT TISSUE REGENERATION IN IMPLANT DENTISTRY Feifei Mao, Nannan Li, Shuhui Chen, Yifei Zhang, Shu He, Shicheng Wei and Jing Chen Academy for Advanced Interdisciplinary Studies, Peking University, China Institution of Micro/Nano electronics, Peking University, China : Both authors contributed equally to this work ABSTRACT Different patterns on Ti substrate which mimic the e...