Recent studies have demonstrated that covalent grafting of a single histidine residue into a twin-chain aliphatic hydrocarbon compound enhances its endosome-disrupting properties and thereby generates an excellent DNA transfection system. Significant increase in gene delivery efficiencies has thus been obtained by using endosome-disrupting multiple histidine functionalities in the molecular arc...

Lactobacillus arabinosus strain 17-5 fails to grow in the absence of phenylalanine or tyrosine during an incubation period in which maximum growth is attained in the presence of these amino acids. However, good growth is observed in media deficient in these amino acids when the incubation time is extended (Dunn et al., 1947; Prescott et al., 1949; James, 1950; Atkinson and Fox, 1951; Borek and ...

The intracellular non-bicarbonate buffering capacity of vertebrate muscle is mainly supported by the imidazole groups of histidine residues in proteins, free L-histidine in some fish species, and histidine-containing dipeptides such as carnosine, anserine, and balenine (ophidine). The proton buffering capacity markedly differs between muscle types and animal species depending on the ability for...

a-Amino acids have been shown to exert a substantial inhibitory effect on the hydrolysis of sodium /3-glycerophosphate by tissue alkaline phosphatases at optimal pH (1). The inhibition by r,-histidine was particularly marked; inhibition constants (Ki) of approximately 6 X 10-S M and 3 X lOma M were obtained for rat intestinal and rat bone phosphatases, respectively (1). The primary concern of t...

Two-component systems (TCSs) aid bacteria in adapting to a wide variety of stress conditions. While the role of TCS response regulators in the cold tolerance of the psychrotrophic foodborne pathogen Listeria monocytogenes has been demonstrated previously, no comprehensive studies showing the role of TCS histidine kinases of L. monocytogenes at low temperature have been performed. We compared th...

Histidine is an amino acid precursor of neuronal histamine. It is evident that peripheral injection of histidine produces effects that resemble to centrally administered histamine. The aim of the present study was to compare the effects of intracerebroventricular (ICV) injection of histamine and inraperitoneal (IP) injection of histidine on food intake in rabbits. ICV injections of histamine (1...

The metabolic syndrome is a risk factor that increases the risk for development of renal and vascular complications. This study addresses the effects of chronic administration of the endogenous dipeptide carnosine (β-alanyl-L-histidine, L-CAR) and of its enantiomer (β-alanyl-D-histidine, D-CAR) on hyperlipidaemia, hypertension, advanced glycation end products, advanced lipoxidation end products...

Amino acid pattern in total saliva was studied in 43 children with caries, aged 12-15 years, using the method of ion exchange chromatography. The results were compared to those obtained in a control group of 39 children without caries. In saliva from the children with caries, a significantly lower level of arginine (22.02 mumol/l), and a complete lack of histidine and its derivatives were obser...