Variation in human DNA sequences account for a significant amount of genetic risk factors for common disease such as hypertension, diabetes, Alzheimer’s disease, and cancer. Identifying the human sequence variation that makes up the genetic basis of common disease will have a tremendous impact on medicine in many ways. Recent efforts to identify these genetic factors through large scale associa...

K E Y W O R D S : abduction, grounded theory, organizational design, qualitative research, military organizations

1 We thank Lisa Kramer for helpful comments and the Social Sciences and Humanities Research Council of Canada for financial support.

Attachment regions of the eukaryotic chromosomal DNA to the nuclear scaffold/matrix (S/MARs) participate in various important cellular processes. However, no obvious characteristics common for these nucleotide sequences have been revealed, except that S/MARs are non-coding sites containing putative regulatory elements and binding sites of DNA-topoisomerase II. Heterogeneity among S/MARs can be ...

VOLUME 89, NO. 3 Infant mortality is a frequently used measure of population health status. Because of concern that Canada’s infant mortality rate (IMR) was rising, Joseph and Kramer examined trends in Canada’s IMR and the effect of registering extremely low birthweight (under 500 grams) infants as live births. A live birth is defined as any infant who, after delivery, “...breathes or shows any...

Water deficit is the major abiotic factor limiting plant growth and crop productivity around the world (Kramer, 1983). Approximately one third of the cultivated area of the world suffers from chronically inadequate supplies of water (Massacci et al., 2008). In all agricultural regions, yields of rain-fed crops are periodically reduced by drought (Kramer, 1983), and the severity of the problem m...