Approximately 90% of all head and neck malignancies and 94% of oral malignancies are squamous cell carcinoma (SCC). Tobacco smoking is considered as the most important causative agent for SCC. Despite aggressive and multidisciplinary treatment approaches, there has been no significant improvement in 5-year survival over the past 20 years. Several prognostic and predictive clinical, pathological...

Although much has been characterized about squamous cell carcinoma of the lower female reproductive tract, there is limited knowledge and experience with cases demonstrating squamous cell carcinoma with sarcomatoid features. Sarcomatoid squamous cell carcinoma (SSCC) is mainly found in the upper aerodigestive tract with the larynx being the most common site in the head and neck region. (Otay et...

Oral carcinogenesis is considered to be a highly complex, molecular and histologically multistage process, which is often localized in the oral cavity, may metastasize and spread out resulting in the onset of Squamous Cell Carcinoma of Head and Neck (SCCHN). Among all the oral cancers, the frequency with which OSCC (Oral Squamous Cell Carcinoma) (arising from the lining mucosa) occurs is the hi...

Squamous cell carcinoma of oral cavity is of malignant tumors, which causes cancerous complications. DNA damage, mainly because of products of oxidative stress like reactive oxygen species, is a frequent mutagenic that triggers carcinoma. Smoking increases the probability of cancer incidence. Saliva is the first biological medium to interact with external compounds, especially smoking substance...

Exfoliative cytology has been widely used for early diagnosis of oral squamous cell carcinoma. We have developed an oral cancer risk index using DNA index value to quantitatively assess cancer risk in patients with oral leukoplakia, but with limited success. In order to improve the performance of the risk index, we collected exfoliative cytology, histopathology, and clinical follow-up data from...

Abstract There is an unexplained male predominance in the incidence of esophageal (EAC) and non-cardia gastric adenocarcinoma (GAC) which cannot be explained by known risk factors. Differences exposures to sex hormones may play a part observed difference. This study aimed test hypothesis that androgens increase EAC, cardia GAC, GAC. We analysed matched cohort based on national Swedish database ...

Fibroblast growth factor receptor 3 (FGFR3) is a member of the fibroblast growth factor receptor tyrosine kinase family. It has been identified as a promising therapeutic target in multiple types of cancer. We have investigated FGFR3 protein expression and FGFR3 gene copy-numbers in a single well-documented cohort of oral and oropharyngeal squamous cell carcinoma. Tissue microarray sets contain...

Oral cancers are among the most common types of cancer. Squamous cell carcinoma accounts for approximately %90 oral cancers. The prognosis in squamous carcinomas differs depending on treatment and size lesion. Treatment options include marginal resection, radiotherapy chemotherapy. Although is an effective option head neck cancers, it known to cause some complications. include. In this case rep...

BACKGROUND AND AIM: The aim of this study was to determine the incidence and relative frequency of oral and pharyngeal cancers in Kermanshah, Iran, from March 1993 until March 2006.METHODS: The data used in this epidemiologic study were extracted directly from pathology records registered in 12 (all) public and private pathology centers of Kermanshah province during the 13-year study period. Th...