In most formulations processed via continuous twin screw granulation microcrystalline cellulose (MCC) and/or lactose are used as excipients, but mannitol is also a preferred excipient for wet granulation and tableting due to its non-hygroscopicity and inertness. Therefore, the aim of the current study was to investigate the influence of process parameters on critical quality attributes of granu...

We give a new proof that all external rays of the Mandelbrot set at rational angles land, and of the relation between the external angle of such a ray and the dynamics at the landing point. Our proof is di erent from the original one, given by Douady and Hubbard and re ned by Lavaurs, in several ways: it replaces analytic arguments by combinatorial ones; it does not use complex analytic depende...

OBJECTIVE The objective of the study was evaluation of work conditions in a pasta manufacturing plant, including: physical and psychological load and factors of material work environment. The main aim was determination of the level of employees' exposure to our dust. METHODS Studies of work conditions were conducted in a our processing plant in the Lublin region at the workplace of an automat...

Back to nature is a trend that being favored by people around the world, including Indonesia. The use of herbal ingredients and traditional medicine has become an inseparable part Indonesian people's lives. This study aims determine types medicinal plants used, parts used how them Pokkang village, Kec. Kalukku, Kab. Mamuju. research qualitative descriptive study. with data collection techniques...

For the natural biparametric family of piecewise linear circle maps with two pieces we show that the entropy increases when any of the two parameters increases. We also describe the regions of the parameter space where the monotonicity is strict. 1. Statement of the results In this paper we study the monotonicity of the entropy for a biparametric family of degree one circle maps. The monotonici...

Interactions of KCA-098 with heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CyD) in solution and in the solid state were studied by the solubility method, UV and fluorescence spectroscopy, powder X-ray diffractometry, and thermal analysis. The KCA-098/DM-beta-CyD system showed an A(L) type solubility diagram with stability constants of 5870 and 2220 M(-1) in aqueous and 10% methanol solut...

| We give a new proof that all external rays of the Man-delbrot set at rational angles land, and of the relation between the external angle of such a ray and the dynamics at the landing point. Our proof is diierent from the original one, given by Douady and Hubbard and reened by Lavaurs, in several ways: it replaces analytic arguments by combinatorial ones; it does not use complex analytic depe...

Captopril (CAP) was the first angiotensin I-converting enzyme (ACE) inhibitor to be developed and is widely used in hypertension treatment. On the other hand, cyclodextrins (CDs) are cyclic oligosaccharides whose cone-shaped cavity allows formation of noncovalent inclusion complexes with appropriately sized guest molecules, thus modifying guest physical, chemical, and biological properties. Her...

Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drugcyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by βcyclodextrin was done by simple com...