The brain mechanism regulating gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) release is sexually differentiated in rodents. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) have been suggested to be sexually dimorphic and involved in the GnRH/LH surge generation. The present study aimed to determine the significance of neonatal testicular androgen to defem...

Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (GPR54 also called KISS1R) are also expressed in the testes but a functional role in this tissue has not been confirmed. We examined which cell types in the testes expressed...

Kisspeptin has been demonstrated to affect reproductive cyclicity and the attainment of puberty in multiple species, presumably through its actions on gonadotropin releasing hormone luteinizing hormone. administration causes increased plasma concentrations LH pigs, sheep, rats. The objective this experiment was evaluate changes hypothalamic kisspeptin system throughout estrous cycle gilts. Estr...

Objective The inhibitory effects of Morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on GnRH/LH release. Hypothalamic kisspeptin is involved in relaying the environmental and metabolic information to reproductive axis. In the present study the role of kisspeptin/GPR54 signaling system was investigated on relaying the inhibitory effects of morphine on LH horm...

background: (PCOS) is among the most common types of gynecological hormonal abnormalities and metabolic problems that have an impact females throughout adolescence, with a prevalence 6-10%.Hyperandrogenism, unreliable menstrual periods, polycystic ovaries are hallmarks PCOS. The (HPG) axis controlled by kisspeptins, peptides made KISS1 gene.Objectives: This investigation's objective about used ...

Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Student Research Committiee, Shiraz University of Medical Sciences, Shiraz, Iran Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences,...