Tissue fibrosis contributes to nearly half of all deaths in the developed world and is characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are mechanically static. Here, we used visible light-mediated stiffening hydrogels to investigate cell mechanotransduction in a disease-relevant system. Primary hepatic stellate cell-seeded hydrogels stiffened in ...

We present a rigorous framework for analyzing timestampbased concurrency control and recovery algorithms for nested transactions. We define a local correctness property, local static atomic@, that affords useful modularity. We show that local static atomicity of each object is sufficient to ensure global serializability. We present generalizations of algorithms due to Reed and Herlihy, and show...

The kinetics of the dark-adapted salamander rod photocurrent response to flashes producing from 10 to 10(5) photoisomerizations (Phi) were investigated in normal Ringer's solution, and in a choline solution that clamps calcium near its resting level. For saturating intensities ranging from approximately 10(2) to 10(4) Phi, the recovery phases of the responses in choline were nearly invariant in...

The permeability estimation from cell monolayer permeation data is usually based on 100% recovery assumption. However, poor recovery is often seen in such experiments in practice but often neglected in data interpretation. In the present study, the cellular retention kinetics during Caco-2 permeation experiments of three passively transported compounds, weakly basic propranolol [(+/-)-1-isoprop...

In the present investigation the distribution of mean velocity, static pressure and total pressure are experimentally studied on an annular curved diffuser of 37.5° angle of turn with an area ratio of 1.284 and centerline length was chosen as three times of inlet diameter. The experimental results then were numerically validated with the help of Fluent and then a series of parametric investigat...

In the present investigation the distribution of mean velocity, static pressure and total pressure are experimentally studied on a C-shape diffuser of 40° angle of turn with an area ratio of 1.278 and centerline length was chosen as three times of inlet diameter. The experimental results then were numerically validated with the help of Fluent and then a series of parametric investigations are c...

Because of the reduced affinity of haemoglobin S to oxygen and the altered blood rheological profile of sickle cell trait carriers (AS), it is often thought that exercise physiological responses should differ between AS and subjects with normal haemoglobin (AA). The present study aimed to compare the ability to remove blood lactate and the characteristics of oxygen uptake (VO2 . ) recovery kine...

Monolithic aerogels of high molecular weight polyethylene (Mw= 3x106- 6x106 g/mol) have been prepared by solvent extraction with supercritical carbon dioxide from thermoreversible gels prepared in decalin. These low density and highly porous aerogels present an apparent porosity up to 90%. The aerogel morphology observed by scanning electron microscopy (SEM) is characterized by spherulitic stru...