objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

background: pantothenate kinase associated neurodegeneration (pkan) is the most prevalent type of neurodegeneration with brain iron accumulation (nbia) disorders characterized by extrapyramidal signs, and 'eye-of-the-tiger' on t2 brain magnetic resonance imaging (mri) characterized by hypointensity in globus pallidus and a hyperintensity in its core. all pkan patients have homozygous or compoun...

background: the b-cell defect in x-linked agammaglobulinemia (xla) is caused by mutations in the gene for bruton's tyrosine kinase (btk). btk mutations result in deficient expression of btk protein in peripheral blood monocytes. methods: using the anti-btk monoclonal antibody (48-2h), a flow cytometric analysis of intra cytoplasmic btk protein expression in monocytes was performed to ident...

background: the purpose of this study is to evaluate effects of teucrium polium (tp) leaf extracts on adenosine monophosphate activated protein kinase (ampk) level in isolated pancreases. materials and methods: in this experimental study, two groups of rats were used as a control group, and diabetic group. in the end of experimental period the animals were sacrificed then pancreas were removed,...

how to cite this article: tonekaboni sh, mollamohammadi m. neurodegeneration with brain iron accumulation: an overview. iran j child neurol. 2014 autumn;8(4): 1-8. abstract objective neurodegeneration with brain iron accumulation (nbia) is a group of neurodegenerative disorder with deposition of iron in the brain (mainly basal ganglia) leading to a progressive parkinsonism, spasticity, dystonia...

introduction: the aim of this study was to assess the effect of ca2+/calmodulin-dependent kinase iiα (camkiiα) inhibitor (kn-93) injection into the locus coeruleus (lc) on the modulation of withdrawal signs. we also sought to study the effect of chronic morphine administration on camkiiα activity in the rat lc. methods: the research was based on behavioral and molecular studies. in the behavior...

background: the cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. this study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. methods: five groups (7 each) of male sprague-dawley rats, including a control group, a diabetes (induced by streptozocin and nicotinamide)...

Keywords: Myotonic dystrophy, Dystrophia Myotonica Protein Kinase (DMPK) gene, Epilepsy, Temporal lobe