Fifty cases of breast carcinoma were investigated for Nm23, LPA1, Ki67 and p53 antigen expression, using immunohistochemical techniques. Correlation between markers was studied. Nm23 showed an inverse correlation with LPA1 and Ki67, and positive with p53. Nm23/LPA1presented significant (p<0.001) negative correlation with p53, but not difference were observed with Ki67. It can be concluded that:...

AIMS To investigate the expression of the genes encoding cyclin D1 and p21 in proliferative and non-proliferative cells, as demonstrated by the Ki67 antibody, and to correlate these findings with differentiation. METHODS Immunohistochemistry and immunofluorescence double staining were performed on three breast cancers, two squamous cell cancers of the head and neck, and one ovarium cystadenoc...

Vasohibin-1 (VASH1) is an identified negative feedback inhibitor of angiogenesis induced by vascular endothelial growth factor (VEGF) in vascular endothelial cells (ECs). Expression of VASH1 has been reported not only in ECs of normal tissue, but also in ECs surrounding malignant tumors. In malignant tumors, VASH1 is also gaining attention as a prognosis prediction marker. The aim of this study...

It is suggested that tumour stromal myofibroblasts exert an unfavourable effect on the biology of breast cancer. We are aware of only a single study which examined relationships between manifestation of myofibroblasts in the stroma of breast cancer and clinicopathological data of the patients. The present study was aimed at estimation of the effect exerted by myofibroblasts present in the tumou...

PURPOSE To determine whether Ki67 expression and breast cancer subtypes could predict locoregional recurrence (LRR) and influence the postmastectomy radiotherapy (PMRT) decision in breast cancer (BC) patients with pathologic negative lymph nodes (pN0) after modified radical mastectomy (MRM). METHODS AND MATERIALS A total of 699 BC patients with pN0 status after MRM, treated between 2001 and 2...

The objective of this study was to identify the frequency of coinfection by human papillomavirus (HPV) and Chlamydia trachomatis (CT) in cervical lesions and relate it with immunohistochemical expression of p16INK4a and Ki67, both oncogenicity markers. A cross-sectional study with 86 women from primary care units in southern Brazil was conducted. Cervical swabs were collected for HPV-DNA and CT...

Aim. To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. Methods. The expressions of GPX1, CDX2, and Ki67 were immunohistochemically evaluated in 172 GAC specimens. The association of GPX1 and CDX2 with patient's clinicopathologica...

Aim. To identify the effect of preterm birth on proliferation and hyperplasia cardiomyocytes in early postnatal period ontogenesis rats. Materials methods. Preterm (on day 21 21.5 gestation) Wistar rats was induced by subcutaneous administration mifepristone. Immunohistochemistry used to calculate number Ki67-positive Mklp2-positive left ventricle full-term days 1, 2, 3, 4, 5, 6 ontogenesis. St...

OBJECTIVE To investigate the expression status of Girdin in glioma and the relationship between Girdin expression and the biological behavior of glioma. MATERIALS AND METHODS The expression status of Girdin in glioma from 560 cases was evaluated by RT-PCR, Western Blot and immunohistochemistry. The relationship between Girdin expression and clinic-pathological parameters as well as prognosis ...

T Summary: Studies have reported the presence of relationships between the Myc target gene Mina53 and poor prognostic factors in several cancers including esophageal cancer. In this study, we investigated the relationships between Mina53 expression in gingival squamous cell carcinoma and clinicopathological factors. Seven samples of normal and dysplastic gingival tissues and 15 samples of gingi...