conclusions we identified a strong association between the t allele of il6r gene polymorphisms (rs2229238, rs4845625) and the risk of t2d in a protective role and as a risk factor, respectively. we also found different bmi and hdl values between the patient group and the control group, respectively in compare genotypes (ct+tt vs. cc). further studies on various ethnicities are necessary to veri...

background chronic renal failure is an important and common complication of diabetes mellitus; hence, renal transplantation is a frequent and the acceptable treatment in patients with diabetic nephropathy requiring renal replacement therapy. on the other hand, renal transplantation and its conventional treatment can lead to increased diabetes outbreak in normoglycemic recipients. also, uncontro...

background: hyperglycemia is one of the important featurs of diabetes. in cell culture studies different methods are used to mimic the hyperglycemia condition. in this study we investigate response of human liver cancer cell line (hepg2) to high insulin, high glucose, and high insulin/ high glucose medium exposure. methods: hepg2 cells were settled in dmem+0.1% fbs or dmem free-serum medium wit...

objective: the present study was hypothesized to investigate the beneficial effects of fresh, aged, and cooked garlic extracts on blood glucose and memory of diabetic rats induced by streptozocine (stz). material and methods: diabetes was induced by an intraperitoneal injection of stz (60 mg/kg body weight). an oral dose of 1000 mg/kg of each garlic extract was given daily for 4 weeks after dia...

Two West Indian men with no previous history of diabetes mellitus developed hyperosmolar non-ketotic diabetic coma. Intra-abdominal catastrophes secondary to mesenteric thrombosis played a major part in the death of these patients, in both of whom control of the hyperosmolar state had been achieved. Both patients had evidence of infarction of intestine at necropsy. Vascular thromboses are a maj...

BERGMAN, E. N. Glycerol furnouer in the nonpregnant and k&tic pregnant sheep. Am. J. Physiol. 215(4): 865-873. 1968.Labeled glycerol was infused intravenously into three groups of sheep: fed, fasted, and twin-pregnant hypoglycemic and ketotic. The turnover time of the free glycerol pool was rapid in all animals (15-l 8 min). Mean glycerol turnover rates were 0.25 mmole/hr per kg3i4 in fed anima...

The rapid association of Na-[16-(14)C]palmitate with isolated rat liver mitochondria was measured by an oil separation method. This association was time and temperature-dependent and was absolutely dependent on the presence of exogenous ATP and CoASH and partially dependent on exogenous carnitine. Carnitine dependence was enhanced at lower concentrations of [(14)C]palmitate. At 6.5 micro M [(14...

Specifically W-labeled fatty acids and 2-amino-4-phenylbutyric acid were administered to fed and starved normal and nonketotic and ketotic diabetic rats. The acetylated amino acid was isolated from their urines, hydrolyzed, and the resulting acetates degraded. The percentage of distribution of 14C! in the acetate from [2-Wlstearate and [2W]palmitate formed by the nonketotic diabetic rats was ab...