The aim of this study was to develop and evaluate the effectiveness of biodegradable nanofibrous lidocaine/ketorolac-loaded anti-adhesion membranes to sustainably release analgesics on abdominal surgical wounds. The analgesic-eluting membranes with two polymer-to-drug ratios (6:1 and 4:1) were produced via an electrospinning technique. A high-performance liquid chromatography (HPLC) assay was e...

Objective: To compare the frequency of opioid requirement, after intravenous lignocaine infusion and ketorolac tromethamine in upper limb surgeries.
 Study Design: Quasi-experimental study.
 Place Duration Study: Combined Military Hospital, Lahore Pakistan, from Oct 2017 to Apr 2018.
 Methodology: ASA I/II patients either gender undergoing surgery were included. Patients randomly...

Objective: While the non-steroidal anti-inflammatory drugs (NSAIDs) represent an important option for the management of acute postoperative pain, their use can be limited due to potential safety concerns, including bleeding risks. This study examined the bleeding-related safety of injectable diclofenac formulated with hydroxypropyl-β-cyclodextrin (HPβCD-diclofenac) when used for postoperative p...

Ketorolac topic. A therapeutic possibility in the Retinopaty of Prematurity? Retrospective Title: cohort study Summary: Objective: Evaluate if the topical ketorolac diminishes the progression of Retinopathy of the Premature one (ROP) to severe stages that have an impact on the visual capacity of the child. Methods: Research of retrospective cohort, design before-and-after. Comparing the need fo...

Ketorolac topic. A therapeutic possibility in the Retinopaty of Prematurity? Retrospective Title: cohort study Summary: Objective: To evaluate whether topical ketorolac diminishes the progression of Retinopathy of the Premature (ROP) to severe stages that have an impact on the visual capacity of the child. Methods: Research of retrospective cohort, design before-and-after, comparing the need fo...

This study evaluates the sustained analgesic effect of ketorolac-eluting thermosensitive biodegradable hydrogel in the plantar incisional pain model of the rat hind-paw. A ketorolac-embedded 2, 2'-Bis (2-oxazolin) (BOX) linking methoxy-poly(ethylene glycol) and poly(lactide-co-glycolide) (mPEG-PLGA) diblock copolymer (BOX copolymer) was synthesized as keto-hydrogel based on optimal sol-gel phas...

During therapeutic interventions, blood concentrations of intravenously applied drugs are higher, and their onset of pharmacological action is faster than with other routes of drug administration. However, acute drug therapy often produces nephrotoxic side effects, as commonly seen after treatment with Ketorolac or Gentamicin leading to questions about their use, especially for patients at risk...

The purpose of this study was to determine whether intravenous ketorolac tromethamine could produce preemptive analgesia in patients undergoing laparoscopic gynecologic surgical procedures. Each patient's response to pain was measured by the mechanical visual analogue scale (M-VAS) and total analgesic use. By using a double-blind design, 49 patients were randomized into the preemptive group (n ...

This retrospective study was undertaken to determine the usefulness of intravenous regional anesthetic (IVRA) blocks containing ketorolac and lidocaine in the management of sympathetically-mediated pain, and to determine what factors, if any, predicted success with this technique. Sixty-one patients with reflex sympathetic dystrophy presenting to a university-affiliated teaching hospital's pain...

Objective: To compare the analgesic efficacy and safety of the single oral ketorolac pre & post operatively for dental extraction pain. and Methods: 49 Patients who were undergoing third molar extraction (impacted or other causes) were recruited into the study, over a period of one year. The patients were divided into four groups to receive ketorolac (20 mg) or placebo either preoperatively or ...