Albumin, the major circulating protein in blood plasma, can be subjected to an increased level of glycation in a diabetic context. Albumin exerts crucial pharmacological activities through its drug binding capacity, i.e., ketoprofen, and via its esterase-like activity, allowing the conversion of prodrugs into active drugs. In this study, the impact of the glucose-mediated glycation on the pharm...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat migraine, but the mechanisms of their effects in this pathology are not fully elucidated. The trigeminal ganglia and calcitonin gene-related peptide (CGRP) have been implicated in the pathophysiology of migraine. The release of CGRP and prostaglandin E2 (PGE2) from freshly isolated rat trigeminal ganglia was evaluated af...

Ketorolac 10 and 20 mg, ketoprofen 50 mg and placebo were compared in a multiple-dose, double-blind, randomized analgesic study that included 150 patients with pain after impacted third molar removal. Patients evaluated their study medication over a 48 h period. Bivariate and multivariate analysis revealed statistically significant differences between the different medications studied, evaluate...

The aim of the study was to produce a model form of a drug of anti-inflammatory activity designed for application in oral cavity. An attempt was made to choose hydrogel vehicle which would ensure not only high pharmaceutical availability of the therapeutic agent but appropriate theological properties of the drug as well. Variant prescriptions with ketoprofen were worked out which differed in th...

The present work consisted of preparing and characterizing composite carbon materials (WRCC) from raw winery residues (WR) activated with zinc chloride to produce a adsorbent. WRCC was used for the adsorption emerging contaminants in aqueous media. presented morphology favorable characteristics process, giving an abundant porous structure pores different sizes. results show WRCC’s effectiveness...

The aim of the present study was to prepare, optimize and characterize ketoprofen proniosomes. The niosomes were prepared using a slurry method followed by in vitro evaluation after embedding the proniosomes-derived niosomes into a carbopol matrix. A central, composite Box-Wilson design was used for the optimization with the total lipid concentration (X1), surfactant loading (X2) and amount of ...

In vivo studies were conducted to compare the activity of three non-steroidal anti-inflammatory drugs as inhibitors of urinary bladder carcinogenesis induced in B6D2F1 (BDF) mice by N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN). Mice received continuous dietary exposure to non-toxic doses of aspirin, sulindac or ketoprofen beginning 1 week prior to the first of eight weekly doses of 7.5 mg OH-...

The effects of three non-steroidal anti-inflammatory drugs (NSAIDs) on the pharmacokinetics of methotrexate were studied in 10 patients with rheumatoid arthritis. Ketoprofen (3 mg kg-1 day-1), flurbiprofen (3 mg kg-1 day-1), piroxicam (20 mg day-1), or a non-NSAID control (paracetamol/acetaminophen) were administered to patients for at least 6 days (13 days in the case of piroxicam to establish...

OBJECTIVE This retrospective study investigated the impact of a required vs an optional remake requirement on student performance in a compounding laboratory course in which students' compounded preparations were analyzed. METHODS The analysis data for several preparations made by students over a 3-year period were compared for differences in the analyzed content of the active principal ingre...