نتایج جستجو برای: keto ester

تعداد نتایج: 42795  

Journal: :Chembiochem : a European journal of chemical biology 2001
F Stauffer E Zizzari C Engeloch-Jarret J P Faurite J Bobálová R Neier

Porphobilinogen synthase condenses two molecules of 5-aminolevulinate in an asymmetric way. This unusual transformation requires a selective recognition and differentiation between the substrates ending up in the A site or in the P site of porphobilinogen synthase. Studies of inhibitors based on the key intermediate first postulated by Jordan allowed differentiation of the two recognition sites...

2013
Frederick Kurzer Alan R. Morgan

tions: The methyl ester 4, preformed from 2 by chromic acid oxidation [4], yields the identical product 5 with uptake of one mole of diazo­ methane. The discharge of the yellow colour of the reactants 3, 4 indicates the disruption of the a,ßdiketo-chromophore by the action of the second molecule of diazomethane. Its incorporation as a spiro-oxirane ring at C-4 is indicated by the l3C NM R spect...

2010
Marilyn G Wiebe Dominik Mojzita Satu Hilditch Laura Ruohonen Merja Penttilä

BACKGROUND The D-galacturonic acid derived from plant pectin can be converted into a variety of other chemicals which have potential use as chelators, clarifiers, preservatives and plastic precursors. Among these is the deoxy-keto acid derived from L-galactonic acid, keto-deoxy-L-galactonic acid or 3-deoxy-L-threo-hex-2-ulosonic acid. The keto-deoxy sugars have been found to be useful precursor...

2005
CAROLINE P. QUILLEY

Hepatic metabolism of prostacydin (PGI,) results in the formation of several biologically inactive lipids and one stable product that has the same chromatographic and biological properties as authentic 6-keto PGE,. Both prostaglandins, 6-keto PGE, and PGI2, hare comparable potency in their antiaggregatory and disaggregatory effects on platelets. They contract the superfused rat stomach strip bu...

Journal: :Hypertension 1980
C P Quilley J C McGiff W H Lee F F Sun P Y Wong

Hepatic metabolism of prostacyclin (PGI2) results in the formation of several biologically inactive lipids and one stable product that has the same chromatographic and biological properties as authentic 6-keto PGE1. Both prostaglandins, 6-keto PGE1 and PGI2, have comparable potency in their antiaggregatory and disaggregatory effects on platelets. They contract the superfused rat stomach strip b...

Journal: :Circulation research 1991
D W Busija C W Leffler

We determined the effects of phorbol 12,13-dibutyrate (PDB), which activates protein kinase C, on pial arteriolar diameter and cerebrospinal fluid (CSF) prostanoid levels in newborn pigs. A closed cranial window was implanted, and the diameter of one pial arteriole was determined by intravital microscopy. In addition, CSF was sampled from under the window, and prostanoid levels (prostaglandin [...

Journal: :Journal of lipid research 1983
D P Hajjar B B Weksler

Among the biochemical processes associated with the atherogenic process are increased aortic cholesteryl ester (CE) accumulation and altered prostaglandin (PG) production. The precise physiological role of PG, particularly prostacyclin (PGI2), in the control of CE metabolism in intact aortic smooth muscle cells remains to be fully elucidated. We report here that cytosolic neutral cholesteryl es...

Journal: :The Journal of biological chemistry 2000
A Baoutina R T Dean W Jessup

Murine and human macrophages rapidly decreased the level of cholesteryl ester hydroperoxides in low density lipoprotein (LDL) when cultured in media non-permissive for LDL oxidation. This process was proportional to cell number but could not be attributed to the net lipoprotein uptake. Macrophage-mediated loss of lipid hydroperoxides in LDL appears to be metal ion-independent. Degradation of ch...

Journal: :Cancer research 1995
T J Smith G D Stoner C S Yang

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent tobacco-specific carcinogen, has been demonstrated to induce lung tumors in animals and is suspected to be a human carcinogen. Cytochromes P450 are the major enzymes responsible for the activation of NNK in microsomes from the lung and liver of rat and mouse, as well as human liver. The present study investigated the enzymes respons...

Journal: :journal of physical & theoretical chemistry 2007
h. aghaie m. monajjemi l. papei

using hartree–fock (hf) and ِِdensity functional theory (dft) calculations the thermodynamic properties such as thermal energy , , thermal enthalpy , , thermal entropy , , thermal gibbs free energy , , heat capacity ,cv, and molecular structures of several species involving in keto↔enol tautomerism related to acetaldehyde (a), 5,5-dimethyl-1,3-cyclohexanedione (dimedone) and  acetylacetone (aa) h...

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