Prostaglandin reductase 2 (PTGR2) is the enzyme that catalyzes 15-keto-PGE2, an endogenous PPARγ ligand, into 13,14-dihydro-15-keto-PGE2. Previously, we have reported a novel oncogenic role of PTGR2 in gastric cancer, where PTGR2 was discovered to modulate ROS-mediated cell death and tumor transformation. In the present study, we demonstrated the oncogenic potency of PTGR2 in pancreatic cancer....

1. During the normal development of the rat, the specific activity of liver ornithine-keto acid aminotransferase exhibits a transient elevation around term, and subsequently increases to adult activity levels during the third postnatal week. 2. The synthetic glucocorticoid triamcinolone, administered as a single injection, produces a marked elevation of the ornithine-keto acid aminotransferase ...

The mono- and disubstituted cholanoic acids present in human feces have been investigated. Extracts of feces were fractionated on silicic acid column and individual bile acids were isolated by preparative thin-layer chromatography. The isolated compounds were studied by gas-liquid chromatography of the methyl esters, partial trimethylsilyl ethers, oxidation products, and trifluoroacetates. The ...

D-Glucuronic acid is a biomass component that occurs in plant cell wall polysaccharides and is catabolized by saprotrophic microorganisms including fungi. A pathway for D-glucuronic acid catabolism in fungal microorganisms is only partly known. In the filamentous fungus Aspergillus niger, the enzymes that are known to be part of the pathway are the NADPH requiring D-glucuronic acid reductase fo...

This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green tea extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007) will increase the resting metabolic rate (RMR) of overweight subjects maintained on a calorie-restricted diet. In this randomized, double-blind, placebo-controlled, crossover trial,...

Introduction Fetal bradycardia due to sentinel events such as placental abruption, cord prolapse or uterine rupture is associated with an increased risk of acidemia at birth. In the absence a event, data regarding neonatal prognosis are scarce, and it seems plausible that depth might be acidosis The objective was determine whether higher umbilical artery birth in term singleton pregnancies requ...

Polyfunctionalized carbazole derivatives have been synthesized by a one-pot reaction between indoles and keto-functionalized nitroolefins. The first step is based on Friedel-Crafts followed acid-promoted microwave-assisted intramolecular cyclization.

In very rare cases severe metabolic acidosis may cause hypotension, respiratory depression and cardiac arrest. Although rare this cause of shock is important because correction of the metabolic acidosis may be life-saving. Mild metabolic acidosis is relatively common in cases of hypoxia and shock, and is an index of the severity of these. Recurrent metabolic acidosis, which reflects failure of ...

Renal tubular acidosis type 1, also called distal renal tubular acidosis, is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciuria, hypocitraturia, and low urinary NH4. Its etiology is variable and includes sporadic, hereditary, and acquired forms. It should be differentiated from other forms of RTA and other causes of metabolic acidosis. Long-term alkali therapy is th...

Low concentrations of branched-chain fatty acids, such as isobutyric and isovaleric acids, develop during the ripening of hard cheeses and contribute to the beneficial flavor profile. Catabolism of amino acids, such as branched-chain amino acids, by bacteria via aminotransferase reactions and -keto acids is one mechanism to generate these flavorful compounds; however, metabolism of -keto acids ...