There are increased interests on using multiphoton imaging and spectroscopy for skin tissue characterization and diagnosis. However, most studies have been done with just a few excitation wavelengths. Our objective is to perform a systematic study of the two-photon fluorescence (TPF) properties of skin fluorophores, normal skin, and diseased skin tissues. A nonlinear excitation-emission-matrix ...

C ERTAIN DERMOSCOPIC STRUCTURES ARE more conspicuous with nonpolarized dermoscopy (NPD), while others are more conspicuous with polarized dermoscopy (PD). The introduction of “hybrid” dermoscopes allows the user to toggle between polarized and nonpolarized light. We found that structures that are more conspicuous with either NPD or PD appear to “blink” when the observer toggles between light mo...

A 60-year-old male presented with a solitary, asymptomatic, erythematous annular plaque on the medial portion of his right distal leg. Clinically, the lesion had central atrophy with peripheral hyperpigmentation, elevation and scaling (Figure 1). The differential diagnosis at clinical examination included: granuloma annulare, angular lichen planus, hypertrophic tinea corporis, and pigmented Bow...

On the face, the important differential diagnosis of pigmented skin lesion is between lentigo maligna, lentigo maligna melanoma, and flat seborrheic keratosis or lentigo seniles (synonymous with flat seborrheic keratosis in our terminology). In this article, we have summarized our experience in this field. Numerous examples for the criteria mentioned are given in the second edition of the Color...

Background: Seborrheic dermatitis affects approximately 2 to 5% of the populace. Interestingly, the term ‘seborrheic dermatitis’ is somewhat a misnomer as there is no direct quantitative relationship between the degree of sebaceous activity and susceptibility to seborrheic dermatitis. Method: A pilot study was performed to initiate assessment of patient satisfaction with oral minocycline and to...

Specific germline activating point mutations in the gene encoding the tyrosine kinase receptor FGFR3 (fibroblast growth factor receptor 3) result in autosomal dominant human skeletal dysplasias. The identification in multiple myeloma and in two epithelial cancers-bladder and cervical carcinomas-of somatic FGFR3 mutations identical to the germinal activating mutations found in skeletal dysplasia...

A 71-year-old man presented with numerous pruritic seborrheic keratoses, with an eruptive onset over the course of 3 months. At presentation, he was also found to have hypopigmented tumors diffusely scattered throughout his body that were found to be mycosis fungoides on histologic examination. A theory regarding the pathophysiology of the development of eruptive seborrheic keratoses in the pre...

BACKGROUND The development of a novel BRAF inhibitor, vemurafenib, has been associated with impressive tumor regression in patients with BRAF-positive stage IV melanoma. In the phase 3 clinical trials, dermatologic toxic effects associated with vemurafenib were described, namely, the development of eruptive squamous cell carcinomas. Herein, 3 cases are presented that highlight the development o...

[This corrects the article DOI: 10.1016/j.ijwd.2015.07.003.].

Dowling-Degos disease is a rare autosomal dominant inherited pigmentary disorder, mostly confined to the flexures. Diagnosis is established based on the clinical and histopathological correlation. The authors describe the clinical case of a female patient with vulvar involvement and multiple seborrhoeic keratoses on her face, neck, and upper trunk. Major and minor clinical manifestations of Dow...