Recently, the uses of intralesional cryosurgery (ILC) have been rapidly expanding in the field of dermatology and oncology. Thus far, ILC has been effectively used to treat keloids, hidradenitis suppurativa (HS), basal cell carcinomas (BCCs), and cutaneous metastases. These conditions can be difficult to treat so it is significant to have an alternative, effective treatment option available. IL...

Keloids are benign, but sometimes painful and/or pruritic, proliferative growths of dermal collagen, usually resulting from excessive tissue response to trauma. Although benign, the social and psychological impact on affected individuals must be considered. Keloids often arise secondary to ear piercing and operative procedures. No single treatment modality is always successful. The more common ...

Background Chest keloids are a difficult sub-group of scars to treat, likely secondary the high wound tension in area that promotes excessive fibroblast proliferation and collagen deposition. Excision adjuvant radiotherapy has been demonstrated as an efficacious treatment for general, but no meta-analysis exists support claims chest keloids. This study aims identify rate recurrence after surgic...

Keloid disease is a fibro-proliferative disorder characterized by excessive deposition of collagen. Keloids has shown high recurrence rate. We undertook this study to determine what factors influence the with aim developing keloid scoring system. This was cohort prospective longitudinal patients who presented keloids, managed surgical excision followed post radiotherapy. Post-surgery were up fo...

Keloids and hypertrophic scars are pathological fibroproliferative disorders characterized by excessive collagen deposition. The affected skin becomes raised thickened, forming firm pink or red plaques. Common causes include trauma, burn, surgery. Multiple studies on keloids have been reported previously, leading to the development of various therapeutic approaches for them, most which remain c...

Tuen Mun Social Hygiene Clinic, 5/F Tuen Mun Eye Centre, 4 Tuen Lee Street, Tuen Mun, N.T., Hong Kong Treatment of keloids is difficult and the response to first line treatment including silicone gel sheet, compression, topical and intralesional steroid are variable. Intralesional cryosurgery (ILC) may be useful for treating some earlobe keloids not responsive to these first line treatments. IL...

Keloids are disfiguring, inflammatory fibroproliferative growths that expand beyond the borders of cutaneous insults. To elucidate regulatory mechanisms in keloid pathogenesis, we performed transcriptional profiling biopsies from keloids as well adjacent non-lesional (NL) skin on African-American participants (n=3). We identified 344 differentially expressed genes (DEGs) between and normal -- 2...

AIM Despite extensive research into keloid scarring etiopathogenesis, no biomarker has led to an effective therapy. Retinoic acid (RA) has been implicated in key functions including cell cycle regulation, apoptosis, and cell differentiation and shown to affect profibrotic factors, including Transforming growth factor β. However, confirmation of the genetic expression and manipulation of this mo...

Therapy for large symptomatic keloids is often plagued with complicated reconstruction manner and recurrence. This article reports a rare treatment combination for a chest keloid with internal mammary artery perforator flap reconstruction and radiation therapy. We excised the keloid and covered the defect with an internal mammary artery perforator flap. Immediate electron-beam irradiation thera...