There are various methods to treat keloid. However, the recurrence of keloidal lesions seems important in this regard. Herein, we report a case of successful treatment of earlobe keloids with imiquimod after shave excision.

Mammalian target of rapamycin (mTOR) is essential in controlling several cellular functions. This pathway is dysregulated in keloid disease (KD). KD is a common fibroproliferative dermal lesion with an ill-defined treatment strategy. KD demonstrates excessive matrix deposition, angiogenesis, and inflammatory cell infiltration. In KD, both total and phosphorylated forms of mTOR and p70(S6K)(Thr4...

Keloids are tumor-like skin scars that grow as a result of the aberrant healing of skin injuries, with no effective treatment. The molecular mechanism underlying keloid pathogenesis is still largely unknown. In this study, we compared microRNA (miRNA) expression profiles between keloid-derived fibroblasts and normal fibroblasts (including fetal and adult dermal fibroblasts) by miRNA microarray ...

A 31-year-old woman, gravida 3, para 2, at 30 weeks of gestation was referred to our institution with the symptom of rapid growth of her keloid scars during her current pregnancy. She was black and had a surgical history of a cesarean delivery and a right vulvar excision for a benign inclusion cyst. The keloid scarring was present at her pfannenstiel incision and also at the site of her right v...

OBJECTIVE To evaluate the effect of copper tripeptide and tretinoin on normal and keloid-producing dermal fibroblasts in a serum-free in vitro model. The cellular response was described in terms of viability and secretion of basic fibroblast growth factor (bFGF) and transforming growth factor-beta1 (TGF-beta1). METHODS Primary cell lines were established from patient facial skin samples obtai...

BACKGROUND A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars. METHODS A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). The efficacy of Silge...

Keloids are benign fibroproliferative tumors with features of raised scar tissue and excessive growth beyond the original border. Keloid scars show extracellular matrix(ECM) deposition rich vasculature. Recently, many studies have revealed important pathways keloid pathogenesis. Herein, we focus on difference between traumatic nontraumatic keloids in a transcriptomic level. To preclude intra-le...

SUMMARY Although combination therapy for keloid including postoperative radiation therapy (RT) is common, the radiation toxicity of RT in a patient with a history of collagen vascular disease has not been fully recognized. We experienced a case of an acute radiodermatitis in a patient with keloid. This patient had a chest keloid because of the bypass surgery for Takayasu's arteritis. After we p...