Selective inhibitors of the adenosine 5'-diphosphate pathway of platelet activation have been used rarely in children in the United States. We report the successful use of ticlopidine, together with aspirin, in a 7-month-old infant with Kawasaki disease complicated by a thrombus in a giant coronary aneurysm that failed to resolve with thrombolytic therapy. Kawasaki disease, coronary aneurysms, ...

BACKGROUND Cardiac involvement was the major leading cause of death in patients with Kawasaki and IVIG administration reduces cardiac complications. The objective of this study was to determine the frequency of cardiovascular complications and duration of fever with regard to the time of intravenous immunoglobulin (IVIG) administration of patients with Kawasaki disease. METHODS This follow-up...

BACKGROUND Accelerated matrix breakdown caused by the increased activity of matrix metalloproteinases (MMPs) and/or the quantitative imbalance between MMP and tissue inhibitor of MMP (TIMP) have been implicated in several pathological conditions. MMP and TIMP may also be involved in the destruction of the coronary arterial wall and the resultant coronary arterial lesions in Kawasaki disease. ...

We report a six-month-old febrile infant presenting with stridor. Later on, he developed typical Kawasaki disease with giant aneurysm of the coronary artery with thrombosis that resolved with an aggressive anticoagulation therapy. The giant aneurysm still persisted a year later. Respiratory illness with stridor is an unusual presentation of Kawasaki disease.

Kawasaki disease is an idiopathic self-limiting systemic vasculitis that most often affects children in the age range 6 months to 5 years. It predominantly affects children of Asian origin, particularly Japanese and Chinese populations (possibly because of genetic susceptibility) but there is an appreciable worldwide incidence. It was first described in 1967 by Tomisaku Kawasaki, a Japanese pae...

1Division of Pediatrics, Medical Center for Allergy and Immune Diseases, Yokohama City Minato Red Cross Hospital, Japan 2Department of Pediatrics, Yokohama City Minato Red Cross Hospital, Japan 3Department of Pediatrics, Kawasaki City Kawasaki Hospital, Japan 4Department of Pediatrics, National Hospital Organization Yokohama Medical Center, Japan 5Department of Allergology, Medical Center for A...

background kawasaki disease (kd) is a vasculitis affecting multi-organ systems including liver and kidneys. kd is diagnosed by some clinical criteria including sterile pyuria, microscopic hematuria, proteinuria due to renal involvement, liver abnormalities manifesting as abnormal liver function tests, gallbladder hydrops, and hypoalbuminemia. objectives the aim of the study was to determine the...

background: improvement of endothelial dysfunction could prevent or delay the occurrence of the atherosclerosis process in patients with kawasaki disease (kd). it is suggested that vitamin c could improve endothelial dysfunction. in this study, we investigated whether administration of vitamin c as a water-soluble antioxidant could be effective in this regard among patients with kd. materials a...

BACKGROUND Kawasaki disease is a systemic vasculitis and may affect cerebral function acutely. The aim of the present study was to measure a number of behaviour and social parameters within a cohort of Kawasaki disease patients. METHODS Parents of children with past diagnosis of Kawasaki disease were recruited to complete several behaviour screening questionnaires. Sixty five sets of question...

Background. Kawasaki disease is an acute self-limited vasculitis of childhood that is characterized by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy. Coronary artery aneurysms or ectasia develop in 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death. Methods a...