Purpose: Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and is elevated in many cancers, including colorectal cancer. We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer–specific survival among colorectal cancer cases, and then investigated its functional significance in colon ca...

While contemporary US and international systemic lupus erythematosus (SLE) consortia (1–3) have greatly advanced our knowledge regarding the disease, many argue that such registries suffer from referral bias and do not accurately represent the spectrum of disease at the population level. In contrast, population-based cohort studies encompass the spectrum of mild through severe cases of SLE and ...

METHODS: We conducted a 16-center, prospective cohort study of hospitalized children aged ,2 years with bronchiolitis during the winters of 2007 through 2010. Patients were classified into 2 groups (normonatremic [135–145 mEq/L] and hyponatremic [,135 mEq/L]) based on the firstmeasured serum sodium concentration on the day of hospitalization. Outcomes were use of mechanical ventilation and ICU ...

Patients with sickle cell anemia (SCA) are at increased risk for developing chronic kidney disease (CKD), and progression to end-stage renal is associated morbidity mortality. Identifying modifiable factors CKD in childhood a vital first step ameliorate progression. SCA may have higher due the unique pathophysiology heme exposure sickling of red blood cells; however, it important evaluate estab...

Gbmez, J., M.A. Fiol and J.L.A. Yebra, Graphs on alphabets as models foi large interconnection networks, Discrete Applied Mathematics 37138 (1992) 227-243. Graphs on alphabets are constructed by labelling the vertices with words on a given alphabet, and specifying a rule that relates pairs of different words to define the edges. They have proved to be quite suitable to model large interconnecti...

Purpose: Taxanes have effects on angiogenesis causing difficulties in separating biological effects of chemotherapy from those due to angiogenesis inhibitors. This randomized phase II trial was designed to evaluate the additional biomarker effect on angiogenesis when bevacizumab is added to docetaxel. Experimental Design: Patients with inoperable breast cancer were randomized to either 2 cycles...

Transposable elements constitute .40% of the human genome; transposition of these elements increases genome instability and cancer risk. Epigenetic mechanisms are important for transcriptional repression of retrotransposons, thereby preventing transposition events. Binding of biotin to histones, mediated by holocarboxylase synthetase (HCS), is a novel histone mark that plays a role in gene regu...

Treatment-resistant depression (TRD) is a prevalent, disabling, and costly condition affecting 1%–4% of the U.S. population. Current approaches to managing TRD include medication augmentation (with lithium, thyroid hormone, buspirone, atypical antipsychotics, or various antidepressant medications), psychotherapy, and ECT. Advances in understanding the neurobiology of mood regulation and depress...

Surgery is a preferred management strategy for numerous gynecologic conditions. In the past decades, breadth of surgery has widely expanded, with general gynecology now encompassing open, vaginal, laparoscopic, and robotic techniques. These advances have improved patient safety in many settings; example, laparoscopic vaginal hysterectomies yield faster postoperative recovery, shorter hospital s...

Histones are heavily post-translationally modified by ubiquitin. Lately, many more ubiquitin-based modifications have been mapped on histones, which far less abundant than the canonical ones but essential to safeguard genome stability.Histones at damaged DNA can be phospho-ubiquitin (i.e., pUb Thr12), resulting in chromatin regions with new properties that impact repair pathways.The discovery o...