Membrane voltage controls the passage of ions through voltage-gated K (K(v)) channels, and many studies have demonstrated that this is accomplished by a physical gate located at the cytoplasmic end of the pore. Critical to this determination were the findings that quaternary ammonium ions and certain peptides have access to their internal pore-blocking sites only when the channel gates are open...

Motivation k-mer-based algorithms have become increasingly popular in the processing of high-throughput sequencing data. These algorithms span the gamut of the analysis pipeline from k-mer counting (e.g. for estimating assembly parameters), to error correction, genome and transcriptome assembly, and even transcript quantification. Yet, these tasks often use very different k-mer representations ...

K channels mediate the selective passage of K(+) across the plasma membrane by means of intimate interactions with ions at the pore selectivity filter located near the external face. Despite high conservation of the selectivity filter, the K(+) transport properties of different K channels vary widely, with the unitary conductance spanning a range of over two orders of magnitude. Mutation of Pro...

Voltage-gated K(+) channels are tetramers formed by coassembly of four identical or highly related subunits. All four subunits contribute to formation of the selectivity filter, the narrowest region of the channel pore which determines K(+) selective conductance. In some K(+) channels, the selectivity filter can undergo a conformational change to reduce K(+) flux by a mechanism called C-type in...

Magnetic resonance spectroscopic imaging (MRSI) is a type of MRI in which both spatial and spectral information are gathered. Unfortunately, the time required to acquire a high-resolution image is prohibitive. Thus, we desire to gather the most informative data possible in the limited time available. The particular choice of a limited set of k-space samples has a tremendous impact on the qualit...

An algorithm (which does not involve the usual Riccati-type equation) for computing t/e gain matrices of the Kalman filter is presented. If the dimension k of the state space is much larger than that of the observation process, the number of nonlinear equations to be solved in each step is of order k rather than k as by the usual procedure.

Image segmentation refers to segmenting or dividing an image which corresponds to objects or different parts of an object. The segmentation is carried out using K-means clustering algorithm, which is a fast and efficient way to segment an image. K-means is one of the most widely used algorithm. We have implemented a color based image segmentation using Kmeans clustering technique. The K-means a...

K+ channels conduct and regulate K+ flux across the cell membrane. Several crystal structures and biophysical studies of tetrameric ion channels have revealed many of the structural details of ion selectivity and gating. A narrow pore lined with four arrays of carbonyl groups is responsible for ion selectivity, whereas a conformational change of the four inner transmembrane helices (TM2) is inv...

Cross-filter K corrections for a sample of “normal” Type Ia supernovae (SNe) have been calculated for a range of epochs. With appropriate filter choices, the combined statistical and systematic K correction dispersion of the full sample lies within 0.05 mag for redshifts z < 0.7. This narrow dispersion of the calculated K correction allows the Type Ia to be used as a cosmological probe. We use ...

Recently, there has k e n a growing interest in investigating signal-adaptive multirate filter banks. I n this paper, we propose a direct method of constructing signal-adaptive orthogonal wavelet filter banks with better energy compaction performance than that of Daubechies wavelet filters of same length. 'The speed of this method is fast. so i t can be constructed in real time.