Garrod (1890), who first differentiated rheumatoid arthritis as a clinical entity, noted that the cervical spine was affected in 178 of his 500 patients. Sharp (1957) found that the cervical spine was affected clinically at some stage of the disease in 40 per cent. of the patients attending the Manchester Rheumatism Centre with rheumatoid arthritis; almost all of these were adults and in some c...

There are several artists that have suffered rheumatic diseases. Even then, they continued their creative activity. Paul Klee suffered from systemic sclerosis, Dufy and Renoir suffered from rheumatoid arthritis and Gaudí and Boticelli had systemic-onset juvenile idiopathic arthritis. The famous noucentism sculptor, Manolo Hugué, presented chronic polyarthritis that suggested rheumatoid arthriti...

HLA antigens were examined in 27 patients with juvenile rheumatoid arthritis. HLA-B27 was found in none. The result was different from most other previously reported studies. The most likely explanation for this difference is the possibility that some patients with juvenile ankylosing spondylitis may have been included among the patients in the other studies.

IgM ACPA 6 (20) 11 (37) 13 (43) Introduction We and others have previously shown that the development of rheumatoid arthritis (RA) is preceded by IgG anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) [1,2]. Furthermore, it was shown that other isotypes of ACPA (IgA and, to a lesser extent, the IgM isotype) also predate the onset of RA [3]. Moreover, smoking has been linked t...

The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95-99%) and has sensitivity comparable to that of the rheumatoid factor (70-75%). The antibodies can be detected very early in the disease and can be used as an indicator for the progression and...

Dr. Jones has in this volume, with the sub-title, comprising " Rheumatoid Arthritis, Osteo-arthritis, and Spondylitis Deformans," given a most excellent epitome of present-day knowledge of the diseases of the rheumatoid class. Agreeing with most modern workers, he makes a sharp distinction between the two' diseases, rheumatoid arthritis and osteo-arthritis, nor does he believe that the former m...