This disease has been defined as systemic arthritis by the International League of Associations for Rheumatology (ILAR) classification of juvenile idiopathic arthritis (JIA), 2 systemiconset juvenile rheumatoid arthritis (JRA) by the American College of Rheumatology Classification, or systemic-onset juvenile chronic arthritis by the European League against Rheumatism classification. Diagnosis o...

Cornea is a major structure of eyes affected in rheumatologic patients. It is important to know corneal findings in rheumatic diseases because it can provide early diagnosis and treatment for systemic disease and reduce the risk of complications as irreversible visual loss. In this article, we will summarize and discuss the corneal findings and the formation mechanisms in the diseases of Sjogre...

Introduction Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disorder of childhood. It is a group of diseases characterized by chronic synovitis, associated with many extra-articular manifestations including pulmonary involvement, usually in the systemic type. Alterations of pulmonary function in JIA may be a complication of the underlying disease or related to treatment wi...

Rheumatoid Arthritis (RA) the musculoskeletal disease of joints, mainly affects elderly people and some cases juvenile rathritis also reported. Until now no particular etiological reason put for initiation and development of the disease. The understanding rheumatoid arthritis has paramount importance, besides no particular mechanisms postulated for etiology have been well documented. In recent ...

Naproxen at 10 mg per kg body weight was compared with aspirin at 80 mg per kg body weight in children suffering from juvenile chronic polyarthritis. It was found to be as effective as aspirin, with certainly no more and possibly fewer gastrointestinal side effects. A long-term tolerance study up to 12 months confirmed that naproxed was a satisfactory nonsteroidal anti-inflammatory drug in the ...

The aim of this article is to review rheumatological diseases that are associated with glucocorticoid-induced osteoporosis or fractures and to perform a critical analysis of the current guidelines and treatment regimens. The electronic database MEDLINE was searched using the date range of July 1986 to June 2009 and the following search terms: osteoporosis, bone mineral density, fractures, syste...

In order to examine the relation of Epstein-Barry virus (EBV) infection to chronic arthritis in children antibodies to EB virus capsid antigen (EBVCA) and rheumatoid arthritis nuclear antigen (RANA) were analysed in sera from 133 patients classified as juvenile rheumatoid arthritis (JRA) or pauciarticular, polyarticular, or systemic juvenile chronic arthritis. Except for an increased frequency ...

Concentrations of serum IgG. IgA, and IgM were determined in 200 patients with juvenile rheumatoid arthritis. The relative frequency distribution of IgG and IgM approached that of a log-normal curve; however, there was marked skewing of the distribution of the serum concentrations of IgA. The prevalence of selective IgA deficiency was 4%. In order to permit further intragroup comparisons, the s...

We report the clinical findings and analysis of the immunoglobulin (Ig) composition of the vitreous of a 10-year-old girl with juvenile rheumatoid arthritis-associated uveitis. The vitreous had a schlieren appearance at the time of pars plana lensectomy and vitrectomy. Analysis of the vitreous fluid revealed marked elevation of IgG, IgM, IgA, and albumin levels relative to vitreous fluids from ...