OBJECTIVES It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases. DESIG...

Joint diseases cause serious medical problems for several million people world-wide and therefore the World Health Organization has designated years 2000-2010 as the Decade of the Bone and Joint (Popko et al.2011). Osteoarthritis (OA) is the most common, and increasingly prevalent, human joint disorder (Dieppe, 2000). It has been estimated that in 1990 12 % of Americans, nearly 21 million peopl...

Targeting chemokines and/or chemokine receptors appears to be an intriguing new approach to treating chronic inflammatory disorders like rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and transplant rejections. The involvement of chemokines and chemokine receptors in inflammatory joint diseases, the in vitro and in vivo characteristics of the chemokine family in inflamma...

The synovium is a specialized tissue lining the synovial joints, bursae, and tendon sheaths of the body. It is affected by various localized or systemic disorders. Synovial diseases can be classified as inflammatory, infectious, degenerative, traumatic, hemorrhagic, and neoplastic. Damage in other intraarticular structures, particularly cartilages, generally occurs as a part of pathologic proce...

Abstract Introduction Multilineage differential potentials and immunomodulatory function of mesenchymal stem cells have led to the birth of subfield of regenerative medicine. More than a thousand clinical trials have been conducted, including clinical trials treating joint diseases, e.g. osteoarthritis and inflammatory arthritis. This review is to summarize preclinical studies of mesenchymal st...

honey bee sting is used in some societies as a treatment of inflammation in joint diseases such as arthritis. to investigate the effect of honey bee venom in reducing inflammation, we selected 30 male wister rats which were divided in to 6 groups. except group 1, all remaining groups received 0.5 ml of complete freund’s adjuvant to induce arthritis. after 9 days, all animals that received adjuv...

BACKGROUND Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wrist and finger joints. Objectives of this study were to compare FOI with ultrasonography (US, by gray-scale (GS) and power Doppler (PD)) and clinical examination (CE) and to esti...

INTRODUCTION The incidence of subclinical hemophilic arthritis is low, with this case reports and literature review, we hope clinicians could pay more attention to the diagnosis of subclinical hemophilic arthritis and prevent the misdiagnosis and mistreatment. CASE PRESENTATION We analyzed the imaging feature, and therapy of a subclinical hemophilia case with hip lesion by reporting its clini...

AIMS To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases. METHODS AND RESULTS Three features of chronic synovitis (enlargement of lining cell layer, cellular density of synovial stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent to 3, strong) and eac...