BACKGROUND The probability of reimbursement is a key factor in determining whether to proceed with or abandon a product during its development. The purpose of this article is to illustrate how the methods of iterative Bayesian economic evaluation proposed in the literature can be incorporated into the development process of new medical devices, adapting them to face the relative scarcity of dat...

This review summarizes recent aspects of (di)nitrogen fixation and (di)hydrogen metabolism, with emphasis on cyanobacteria. These organisms possess several types of the enzyme complexes catalyzing N(2) fixation and/or H(2) formation or oxidation, namely, two Mo nitrogenases, a V nitrogenase, and two hydrogenases. The two cyanobacterial Ni hydrogenases are differentiated as either uptake or bidi...

We estimated the relative contribution of atmosphere (ic Nitrogen (N) input (wet and dry deposition and N fixation) to the epipelagic food web by measuring N isotopes of different functional groups of epipelagic zooplankton along 23°W (17°N-4°S) and 18°N (20-24°W) in the Eastern Tropical Atlantic. Results were related to water column observations of nutrient distribution and vertical diffusive ...

Facile methoxymethylation of N(2)-derived nitride NMo(N[(t)Bu]Ar)(3) provided the imido cation [MeOCH(2)NMo(N[(t)Bu]Ar)(3)](+) as its triflate salt in 88% yield. Treatment of the latter with LiN(SiMe(3))(2) provided blue methoxyketimide complex MeO(H)CNMo(N[(t)Bu]Ar)(3) in 95% yield. Conversion of the latter to the terminal cyanide complex NCMo(N[(t)Bu]Ar)(3), which was the subject of a single-...

Bitterbrush (Purshia tridentata) and mahala mat (Ceanothus prostratus) are common N-fixing shrubs in interior forests of the western United States, yet their contribution to ecosystem N pools is poorly characterized. We compared N fixation and soil N accretion by these shrubs in oldgrowth ponderosa pine (Pinus ponderosa)–Jeffrey pine (Pinus jeffreyi) stands versus stands that had been harvested...

PURPOSE Perceptual instability in infantile nystagmus syndrome (INS) has been reported occasionally. This study was conducted to examine the factors that influence perceptual stability in 18 individuals with INS. METHODS The subjects were instructed to look continuously at a fixation LED centered in an image (38 degrees x 32 degrees ) at two luminance levels (3.25 and 0.46 cd/m(2), with 21% a...

The concept of a high-performance total knee replacement has gained prominence because of continued technological improvements by implant manufacturers and the changing expectations of an increasingly younger, more active patient population. Improvements in surgical technique, instrumentation, implant design, biomaterials, and implant fixation have occurred in recent years. The literature is in...

The use of pin fixation for grafts in the femoral tunnel in anterior cruciate ligament (ACL) reconstruction is becoming more popular. The transtibial stiff femoral guides are necessary to ensure that the pins fix the graft. However, the cross pins can sometimes miss the femoral tunnel. As a result of some technical problems that we encountered, we introduced an extra step in the technique of th...

Bone drilling is an essential part of many orthopaedic surgery procedures, including those for internal fixation and for attaching prosthetics. Estimation and control of bone drilling forces are critical to prevent drill-bit breakthrough, excessive heat generation, and mechanical damage to the bone. An experimental and computational study of drilling in cortical bone has been conducted. A 3D fi...

Twenty patients who had been treated with Ilizarov external fixation for a Gustilo grade IIIB supracondylar fracture of the femur were functionally assessed 12 to 52 months after treatment. Fourteen fractures were type C3 and 6 were type C2 according to the AO classification. Fractures were united at an average of 39 +/- 9 weeks. There was a final knee extension deficit of 5 degrees to 10 degre...