Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adhesion molecule-A (JAM-A) regulates the planar orientation of the mitotic spind...

RATIONALE Besides their essential role in hemostasis, platelets also have functions in inflammation. In platelets, junctional adhesion molecule (JAM)-A was previously identified as an inhibitor of integrin αIIbβ3-mediated outside-in signaling and its genetic knockdown resulted in hyperreactivity. OBJECTIVE This gain-of-function was specifically exploited to investigate the role of platelet hy...

Evaluation of biomarkers of arterial hypertension (AH) could be considered to be useful as early, more reliable and accurate diagnostic indicators for AH than simply measuring of blood pressure (BP) in routine clinical practice, especially at early stages of hypertension. For instance, an increased level of a soluble protein junctional adhesion molecule-A (JAM-A) was previously found to be asso...

Evaluation of biomarkers of arterial hypertension (AH) could be considered to be useful as early, more reliable and accurate diagnostic indicators for AH than simply measuring of blood pressure (BP) in routine clinical practice, especially at early stages of hypertension. For instance, an increased level of a soluble protein junctional adhesion molecule-A (JAM-A) was previously found to be asso...

In this study, the interactions of enterohemorrhagic Escherichia coli (EHEC) O157 strains with human ileocecal (HCT-8) epithelial cells and HEp-2 cells were examined. EHEC adhered to, but did not invade, HCT-8 cells by the localized adherence mechanism and a heretofore unrecognized pattern which we called log jam. The log jam formation was (i) not observed on HEp-2 cells, (ii) independent of th...

Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described r...

The health awareness recently shown by consumers has led to a demand for health beneficial products. In particular, researchers are currently focusing their studies on the search for foods for cancer prevention activity. In the present work, we study comparatively the effect of two different processing methods on the contents of phenolic compounds (i.e., ellagic acid, myricetin, quercetin and k...

We study the phase diagram of the continuum traffic flow model of a highway with an on-ramp. Using an open boundary condition, traffic states and metastabilities are investigated numerically for several representative values of the upstream boundary flux f(up) and for the whole range of the on-ramp flux f(rmp). An inhomogeneous but time-independent traffic state (standing localized cluster stat...

Kaptein RG and Van Gisbergen JAM. Effect of gravity cues on spatial updatingduring sinusoidal rotation. Program No. 168.6. Abstract viewer/Itinerary Planner.Washington, DC: Society for Neuroscience, 2005 Kaptein RG and Van Gisbergen JAM. Bistable perception of verticality duringroll tilt. Program No. 868.3. Abstract Viewer/Itinerary Planner. Washington, DC:Society for Neuroscien...

Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D) is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the reovirus receptor Junction Adhesion Molecule-A (JAM-A) on the target cells. Here, we describe th...