There is increasing interest in the use of combination therapy for rheumatoid arthritis and in the possibility of combining the conventional drug approach with newer biological therapies. Animal models of arthritis provide important tools for evaluating novel forms of therapy and for eludicating mechanisms of drug action. In this paper, we review the results of our own research into combination...

Objective: To compare patients who received preoperative intravenous (IV) plus postoperative maintenance IV tranexamic acid (TXA) therapy and perioperative periarticular TXA to those did not receive during total knee arthroplasty (TKA) in terms of blood loss, transfusion requirements, length hospital stay.
 Material Method: Data from 194 underwent TKA between 2016 2019 were reviewed. A 106...

background : vaginismus is an involuntary spasm of the muscles of the outer third of the vagina caused by real or anticipated attempt of vaginal penetration.  it could lead to marital disharmony, guilt feeling and depression.  cognitive behavioral models for therapy of this disorder have gained considerable attention during last three decades.   objective: to determine the efficacy of self-fing...

Treatment of class V+IV lupus nephritis remains unsatisfactory despite the progress made in the treatment of diffuse proliferative lupus nephritis. In this prospective study, 40 patients with class V+IV lupus nephritis were randomly assigned to induction therapy with mycophenolate mofetil, tacrolimus, and steroids (multitarget therapy) or intravenous cyclophosphamide (IVCY). Patients were treat...

A 49-year-old woman suffering from rapidly progressing right-sided heart failure assessed as World Health Organization functional class (WHO-FC) IV is described. After treatment with oxygen and diuretics, she was in WHO-FC III on admission to our hospital, as confirmed by her poor exercise tolerance in cardiopulmonary exercise testing. Upon detailed examination, she was diagnosed as having idio...

Optimizing anemia management is the sole indication for intravenous (IV) iron administration in the patient with chronic kidney disease (CKD): Achieving and maintaining iron sufficiency is crucial to achieving and maintaining target-range hemoglobin (Hgb). Although pica (geophagia) (1) and restless legs syndrome (2,3) may arise in iron-deficient patients, available reports on the efficacy of IV...

To assess the safety of combined intervention in acute myocardial infarction, a pilot study of thrombolysis and beta-adrenergic blockade was performed. Twenty-five subjects were randomized to therapy with intravenous (IV) metoprolol and IV streptokinase (group 1) or to IV metoprolol (group 2) alone. Two-dimensional echocardiography was performed before intervention and five days later. The mean...