Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ...

Funnel chest, with its considerable sternal depression and obvious interference with the topography of the heart, has for some time been made the subject of the attractive paradox that, in the vast majority of cases, it has no effect on cardiac function. True, it is conceded that the deformity may in rare instances be responsible for decompensation severe enough to cause congestive failure but ...

S. M. Robinson published in 1980 a powerful theorem about solutions to certain “generalized equations” corresponding to parameterized variational inequalities which could represent the first-order optimality conditions in nonlinear programming, in particular. In fact, his result covered much of the classical implicit function theorem, if not quite all, but went far beyond that in ideas and form...

Gephyrin is a protein involved in both synaptic anchoring of inhibitory ligand-gated ion channels and molybdenum cofactor synthesis. Substantial progress has been made in understanding its gene and protein structures. Furthermore, numerous binding partners of gephyrin have been identified. The mechanisms by which these interactions occur are unclear at present. Alternative splicing has been pro...

This paper reviews the method of model-fitting via the empirical characteristic function. The advantage of using this procedure is that one can avoid difficulties inherent in calculating or maximizing the likelihood function. Thus it is a desirable estimation method when the maximum likelihood approach encounters difficulties but the characteristic function has a tractable expression. The basic...

The meaning of the wave function and its evolution are investigated. First, we argue that the wave function in quantum mechanics is a description of random discontinuous motion of particles, and the modulus square of the wave function gives the probability density of the particles being in certain locations in space. Next, we show that the linear non-relativistic evolution of the wave function ...

read a paper to the American Neurological Association in Atlantic City in which he described results of stimulating the cerebral cortex in 163 awake adults undergoing intracranial surgery. Later that year he published , with Edwin Boldrey (1906–88), 'Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation' (Brain 1937: 60; 389–443). Section 28...

Correspondence: Dr. Shiva Raj K.C. MBBS, MD Department of Pathology KIST medical college, Imadole, Lalitpur, Nepal Email: [email protected] Abstract: Thyroid diseases are among the most prevalent of medical conditions. In the patients with obvious features of hypothyroidism or hyperthyroidism thyroid function tests only confirm the diagnosis. Though TSH is widely used as a screening test i...